Product image of Lamictal Dispers (Lamotrigine) supplied by GNH India

Lamictal Dispers

Active Ingredient:
Lamotrigine
Origin:
EU

Lamictal Dispers (Lamotrigine)

Lamotrigine, the active ingredient in Lamictal Dispers, is an anticonvulsant presented as an oral formulation for oral use. It is used to treat epilepsy and to stabilize mood in bipolar disorder patients.

GNH India supplies Lamictal Dispers as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline B.V.

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Indications & Clinical Uses

Lamotrigine is an anticonvulsant that acts on neuronal sodium channels to control seizure activity and mood instability.

  • Epilepsy: Reduces the frequency of focal and generalized seizures.
  • Bipolar disorder: Stabilizes mood and lowers the risk of depressive and manic episodes.
  • Seizure disorders: Provides adjunctive therapy for patients whose seizures are not fully controlled by other antiepileptic drugs.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, which stabilises neuronal membranes and diminishes the release of excitatory neurotransmitters such as glutamate. This action reduces neuronal hyperexcitability, helping to prevent seizure propagation and mood swings associated with bipolar disorder.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: Transient sensation of light‑headedness.
  • Headache: Mild to moderate pain often relieved with simple analgesics.
  • Nausea: Stomach discomfort that may improve with food.
  • Rash: Skin irritation that should be monitored.
  • Fatigue: General feeling of tiredness.
  • Blurred vision: Temporary visual disturbances.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: Severe skin reaction requiring immediate medical attention.
  • Toxic epidermal necrolysis: Life‑threatening skin detachment.
  • Blood dyscrasias: Abnormal blood counts such as agranulocytosis.
  • Hepatic failure: Significant liver injury.
  • Severe skin reactions: Including drug reaction with eosinophilia and systemic symptoms (DRESS).

Precautions & Warnings

Lamotrigine requires careful monitoring to minimise risks.

  • Dose titration: Increase gradually to lower the chance of rash.
  • Skin monitoring: Inspect for any rash or hypersensitivity signs.
  • Hepatic function: Adjust dosing in patients with liver impairment.
  • Concomitant valproate: May raise lamotrigine levels; dose adjustment may be needed.
  • Pregnancy: Risk category unknown; discuss benefits and risks with a healthcare professional.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamotrigine interacts with several medicines that can alter its plasma concentration.

Major Interactions (Avoid)

  • Valproic acid: Significantly increases lamotrigine levels; may require dose reduction.
  • Carbamazepine: Lowers lamotrigine concentrations, potentially reducing efficacy.
  • Phenobarbital: Decreases lamotrigine levels, risking loss of seizure control.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: May reduce lamotrigine levels; monitor seizure frequency.
  • Serotonergic agents: Potential for serotonin syndrome; observe for symptoms.
  • SSRIs and other antidepressants: May increase rash risk; watch for skin changes.

Frequently Asked Questions

Lamictal Dispers contains lamotrigine, which is prescribed to control seizures in epilepsy and to stabilize mood in patients with bipolar disorder. It helps reduce the frequency of seizures and prevents the recurrence of depressive or manic episodes when used as part of a comprehensive treatment plan.

Lamotrigine works by blocking voltage‑gated sodium channels on neurons, which stabilises the neuronal membrane and reduces the release of excitatory neurotransmitters such as glutamate. This dampens abnormal electrical activity in the brain, thereby decreasing seizure occurrence and mood fluctuations.

The specific dose of Lamictal Dispers is determined by the prescribing clinician based on the individual’s medical condition, age, weight, and response to therapy. Dosage adjustments may be needed during treatment initiation, when combined with other medications, or in special populations.

The safety of lamotrigine in pregnancy and lactation is not fully established. Healthcare providers weigh potential benefits against possible risks and may adjust therapy accordingly. Women who are pregnant, planning pregnancy, or breastfeeding should discuss their treatment options with a qualified professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lamotrigine differs from many anticonvulsants by primarily targeting sodium channels and having a favourable profile for mood stabilization in bipolar disorder. Compared with older agents such as carbamazepine, it generally has fewer drug‑induced enzyme interactions but requires careful titration to minimise skin‑related adverse events.

Lamictal Dispers should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Lamictal Dispers is taken orally, usually with or without food, as directed by a healthcare professional. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood disorders like agranulocytosis, and significant liver injury. Immediate medical attention is required if any signs of rash, fever, or unusual bleeding occur.

Lamictal Dispers is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Patients with a history of severe skin reactions to lamotrigine or related compounds should avoid this medication. Clinicians should also assess suitability in patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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