Product image of Lamictal (Lamotrigine) supplied by GNH India

Lamictal

Active Ingredient:
Lamotrigine
Origin:
EU

Lamictal (Lamotrigine)

Lamotrigine, the active ingredient in Lamictal, is a sodium channel blocker presented as a tablet for oral use. It treats epilepsy and bipolar disorder in adults and children as prescribed.

GNH India supplies Lamictal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Trading Services Limited

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Indications & Clinical Uses

  • Lamotrigine is used in neurological and psychiatric conditions that involve abnormal neuronal firing.
  • Epilepsy: reduces the frequency and severity of seizures.
  • Bipolar disorder: stabilises mood and helps prevent depressive episodes.
  • Generalized seizures: assists in controlling tonic‑clonic seizure activity.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, which stabilises neuronal membranes and diminishes the release of excitatory neurotransmitters such as glutamate. This reduction in neuronal hyper‑excitability underlies its antiepileptic and mood‑stabilising effects.

Side Effects

Lamotrigine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Rash or mild skin irritation.
  • Headache.
  • Dizziness.
  • Nausea.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe blood dyscrasias such as agranulocytosis.
  • Hepatic failure or significant liver enzyme elevation.

Precautions & Warnings

  • Before prescribing Lamotrigine, clinicians should consider several safety factors.
  • Pregnancy: Category B – use only when the benefit outweighs potential risk.
  • Renal impairment: dose may need adjustment; monitor renal function.
  • Hepatic impairment: monitor liver enzymes and adjust dose if necessary.
  • Concomitant valproate: increased risk of rash; close monitoring required.
  • Avoid abrupt discontinuation: may precipitate seizure recurrence.
  • Store at ambient temperature: keep in the original container, protect from moisture.

Avoid Interactions

Lamotrigine interacts with several medicines that can alter its plasma levels or increase toxicity.

Major Interactions (Avoid)

  • Valproic acid: raises lamotrigine concentrations, heightening rash risk.
  • Carbamazepine: lowers lamotrigine levels, potentially reducing efficacy.
  • Phenobarbital: decreases lamotrigine concentrations, may require dose increase.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: can increase lamotrigine levels; dose adjustments may be needed.
  • Serotonergic agents: monitor for signs of serotonin syndrome.
  • Other antiepileptics (e.g., phenytoin): may modify lamotrigine metabolism.

Frequently Asked Questions

Lamictal, whose active ingredient is lamotrigine, is prescribed for the management of epilepsy, including various seizure types, and for bipolar disorder as a mood stabiliser that helps prevent depressive episodes. It is used in both adult and paediatric populations under medical supervision.

Lamotrigine works by blocking voltage‑gated sodium channels on neurons. This action stabilises neuronal membranes and reduces the release of excitatory neurotransmitters such as glutamate, thereby decreasing abnormal electrical activity that leads to seizures and mood swings.

The appropriate dose of Lamictal is determined individually by a prescriber based on the patient’s condition, age, weight, and any concomitant medications. Dosage titration is essential to balance efficacy with safety, and patients should follow the prescribing clinician’s instructions.

Lamictal is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy only if the potential benefit justifies the risk. Lamotrigine does pass into breast milk, so breastfeeding decisions should be made with a healthcare professional.

To request Lamictal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, lamotrigine generally has a lower risk of drug‑induced hyponatraemia but a higher potential for skin reactions. Its mood‑stabilising properties also make it a preferred option for patients with comorbid bipolar disorder.

Lamictal tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging to protect from moisture and light, and store them out of reach of children.

Lamictal is taken orally, usually as a tablet, with or without food. The exact dosing schedule—once or twice daily—depends on the prescriber’s plan and any other medications the patient is receiving.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, as well as rare blood disorders like agranulocytosis and significant liver injury. Immediate medical attention is required if any signs of these conditions appear.

Lamictal should be avoided in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Patients with a history of severe skin reactions to antiepileptic drugs, or those who cannot be monitored for hepatic or haematologic toxicity, should not be prescribed this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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