Product image of Lamictal (Lamotrigine) supplied by GNH India

Lamictal

Active Ingredient:
Lamotrigine
Origin:
EU

Lamictal (Lamotrigine)

Lamotrigine, the active ingredient in Lamictal, is a sodium channel blocker presented as an oral tablet for oral use. It is prescribed for the management of epilepsy and for mood stabilization in bipolar disorder.\n\nGNH India supplies Lamictal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline Single Member A.E.B.E.

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Indications & Clinical Uses

  • Lamotrigine acts on neuronal sodium channels to control seizure activity and stabilize mood in bipolar disorder.\n\nEpilepsy: reduces the frequency and severity of seizures across various seizure types.\nBipolar disorder: provides maintenance therapy to prevent depressive and manic episodes.\nAdjunct therapy in refractory epilepsy: used alongside other antiepileptic drugs when seizures are not controlled by monotherapy.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, decreasing neuronal excitability and stabilising neuronal membranes. This action reduces the release of excitatory neurotransmitters such as glutamate, thereby diminishing seizure propagation and contributing to mood stabilization in bipolar disorder.

Side Effects

  • Lamotrigine may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Dizziness\n- Headache\n- Nausea or vomiting\n- Skin rash\n- Insomnia\n- Blurred vision\n\nSerious or Rare Side Effects:\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Severe skin reactions (e.g., bullous dermatitis)\n- Blood dyscrasias such as agranulocytosis\n- Hepatic failure\n- Anaphylactic reactions\n- Multi‑organ hypersensitivity syndrome

Precautions & Warnings

  • Lamotrigine requires careful monitoring and patient education to minimise risks.\n\nPregnancy: consult the prescriber as safety data are limited.\nRenal impairment: dose may need adjustment and renal function should be monitored.\nHepatic impairment: monitor liver enzymes and consider dose modification.\nConcomitant valproate: increased risk of severe skin reactions; dosage adjustments are recommended.\nAvoid abrupt discontinuation: may precipitate seizure recurrence or mood destabilisation.\nStore at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

  • Lamotrigine interacts with several medicines that can alter its plasma concentration or increase toxicity.\n\nMajor Interactions (Avoid):\n- Valproic acid: markedly raises lamotrigine levels and risk of serious skin reactions.\n- Carbamazepine: significantly reduces lamotrigine concentrations, potentially diminishing efficacy.\n\nModerate Interactions (Monitor Closely):\n- Oral contraceptives: may lower lamotrigine levels; dose adjustments might be needed.\n- Rifampin: induces metabolism, decreasing lamotrigine exposure.\n- Serotonergic agents (e.g., SSRIs): monitor for signs of serotonin syndrome.

Frequently Asked Questions

Lamictal, whose active ingredient is lamotrigine, is prescribed for the treatment of epilepsy to control various seizure types and for bipolar disorder as a maintenance therapy that helps prevent mood swings and depressive episodes.

Lamotrigine blocks voltage‑gated sodium channels on neurons, reducing abnormal electrical activity and limiting the release of excitatory neurotransmitters such as glutamate. This stabilises neuronal membranes, which underlies its anticonvulsant and mood‑stabilising effects.

The dose of Lamictal is individualized by the prescribing clinician based on the patient’s condition, age, concomitant medications and renal or hepatic function. Only a qualified health professional should determine the appropriate dosing regimen.

Safety data for lamotrigine in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamictal.

To request Lamictal, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, lamotrigine has a broader spectrum for seizure types and a lower risk of drug‑induced hyponatraemia. However, it carries a unique risk of severe skin reactions, especially when combined with valproate, which requires careful monitoring.

Lamictal tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and light, and ensure they are out of reach of children.

Lamictal is taken orally, usually with or without food, as a tablet. The exact administration schedule—once daily or divided doses—depends on the prescriber’s instructions and the patient’s therapeutic needs.

The most serious adverse events include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias, hepatic failure, and anaphylaxis. Prompt medical attention is required if any signs of these reactions appear.

Lamictal is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Patients with a history of severe skin reactions to antiepileptic drugs should avoid it, and it should be used with caution in those with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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