Product image of Lamisil At (Terbinafine Hydrochloride) supplied by GNH India

Lamisil At

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil At (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil At, is an allylamine antifungal presented as a topical formulation for skin use. It treats dermatophyte infections of the skin such as athlete's foot, ringworm and jock itch by eliminating the causative fungus.
GNH India supplies Lamisil At as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Lamisil At is an allylamine antifungal indicated for dermatophyte skin infections.

  • Athlete's foot (tinea pedis): reduces fungal growth and clears infection of the feet.
  • Ringworm (tinea corporis): alleviates lesions and prevents spread across the body.
  • Jock itch (tinea cruris): improves itching and resolves rash in the groin area.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This blockage leads to accumulation of toxic squalene and depletion of ergosterol, causing fungal cell death and resolution of the infection.

Side Effects

Lamisil At may cause local skin reactions and, in rare cases, systemic effects.

Common Side Effects

  • Burning sensation at the application site
  • Itching or pruritus
  • Redness or erythema
  • Dryness or peeling of the skin
  • Scaling or flaking
  • Mild irritation

Serious or Rare Side Effects

  • Severe allergic reaction (angioedema, swelling)
  • Contact dermatitis with extensive rash
  • Blistering or bullous skin lesions
  • Systemic absorption leading to liver enzyme elevation
  • Unexplained fever or malaise
  • Persistent swelling or ulceration at the site

Precautions & Warnings

Before using Lamisil At, consider the following safety measures.

  • Apply to intact skin only: avoid broken skin, mucous membranes, or open wounds.
  • Limit use to affected areas: do not cover large body surface areas without medical advice.
  • Avoid if known hypersensitivity to terbinafine or formulation excipients.
  • Consult a healthcare professional before use in children, elderly, or patients with liver disease.
  • Discontinue if severe irritation, rash, or swelling develops.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Terbinafine may interact with other medications or substances.

Major Interactions (Avoid)

  • Systemic antifungals (e.g., itraconazole): may increase systemic exposure to terbinafine.
  • Strong CYP450 inhibitors (e.g., ketoconazole): can raise terbinafine levels and risk toxicity.
  • Topical corticosteroids: may reduce the antifungal efficacy of Lamisil At.

Moderate Interactions (Monitor Closely)

  • Alcohol consumption: may increase skin irritation.
  • Other topical agents (e.g., salicylic acid, urea): could affect absorption or cause irritation.
  • Hormonal contraceptives: limited data, monitor for any changes in efficacy.

Frequently Asked Questions

Lamisil At is a topical antifungal medication containing terbinafine hydrochloride, indicated for the treatment of dermatophyte infections of the skin such as athlete's foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris). It works by eliminating the fungus that causes these conditions, helping to relieve symptoms and clear lesions.

Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By blocking this pathway, the drug causes accumulation of toxic squalene and depletion of ergosterol, leading to fungal cell death and resolution of the infection.

The specific dosage and duration of Lamisil At are determined by the prescribing healthcare professional based on the type and severity of the infection, the area of skin involved, and patient factors. The prescriber will provide instructions on how much product to apply, how often, and for how many days.

Safety data for topical terbinafine during pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and only under the guidance of a qualified healthcare provider. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and assists with any necessary import documentation.

Lamisil At (terbinafine) belongs to the allylamine class, which acts by inhibiting squalene epoxidase, whereas azole antifungals block lanosterol 14α‑demethylase. Allylamines often achieve faster fungal clearance and are effective against dermatophytes, while azoles have a broader spectrum but may require longer treatment. Choice depends on infection type, patient tolerance, and physician preference.

Lamisil At should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, direct sunlight, and excessive heat. Do not freeze the product, and keep it out of reach of children.

The medication is applied topically to the affected skin area. Clean and dry the skin, then spread a thin layer of the cream or gel over the lesion and a small margin of surrounding healthy skin, usually once or twice daily as directed by the prescriber. Wash hands after application unless treating the hands.

Although rare, serious adverse reactions can occur, including severe allergic responses such as angioedema, widespread skin blistering, or systemic effects like liver enzyme elevation. If any signs of swelling, difficulty breathing, extensive rash, or jaundice develop, discontinue use immediately and seek medical attention.

Individuals with a known hypersensitivity to terbinafine or any component of the formulation should avoid using Lamisil At. It is also contraindicated on broken skin, mucous membranes, or extensive body surface areas without medical supervision. Patients with severe liver disease or those taking interacting systemic medications should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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