Product image of Lamisil At (Terbinafine Hydrochloride) supplied by GNH India

Lamisil At

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil At (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil At, is an allylamine antifungal presented as a topical formulation for skin use. It treats dermatophyte infections of the skin and nails, such as athlete’s foot, ringworm, and jock itch, in adult and pediatric patients.

GNH India supplies Lamisil At as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU market standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil At is an allylamine antifungal used to treat infections caused by dermatophyte fungi.

  • Tinea corporis: clears the skin rash and eliminates the causative fungus.
  • Tinea pedis: reduces itching and resolves athlete’s foot lesions.
  • Tinea cruris: alleviates inflammation in the groin area and eradicates fungal growth.
  • Tinea barbae: treats fungal infection of the beard region, restoring normal skin.
  • Dermatophytosis: provides broad‑spectrum control of skin‑surface fungal infections.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to accumulation of toxic squalene and ultimately causing fungal cell death without affecting human cells.

Side Effects

Common Side Effects

  • Itching at the application site: mild to moderate discomfort.
  • Burning sensation: transient warmth during use.
  • Redness: localized erythema.
  • Scaling or flaking: dry skin patches.
  • Irritation: occasional stinging.
  • Dryness: reduced skin moisture.

Serious or Rare Side Effects

  • Allergic reaction: swelling, hives, or difficulty breathing.
  • Severe skin rash: widespread redness or blistering.
  • Stevens‑Johnson syndrome: rare but life‑threatening mucocutaneous reaction.
  • Contact dermatitis: persistent inflammation at the site.
  • Urticaria: sudden hives.
  • Facial swelling: indicates systemic hypersensitivity.

Precautions & Warnings

Before using Lamisil At, consider the following precautions.

  • Pregnancy: consult a healthcare professional before application.
  • Breastfeeding: discuss potential risks with a physician.
  • Age restrictions: not recommended for children under 2 years unless directed by a clinician.
  • Pre‑existing skin conditions: avoid use on eczematous or inflamed skin.
  • Occlusion: do not cover the treated area with airtight dressings.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine topical may interact with other skin‑applied agents.

Major Interactions (Avoid)

  • Systemic terbinafine: concurrent use can increase systemic exposure.
  • Other topical antifungals: may cause additive irritation.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Alcohol‑based cleansers: can increase skin dryness.
  • Phototoxic agents: monitor for increased skin sensitivity to light.

Frequently Asked Questions

Lamisil At is a topical antifungal indicated for the treatment of dermatophyte infections such as tinea corporis (ringworm), tinea pedis (athlete’s foot), tinea cruris (jock itch), tinea barbae, and other forms of dermatophytosis affecting the skin.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to accumulation of toxic squalene and ultimately causes fungal cell death while sparing human cells.

The specific dose and frequency of Lamisil At are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil At.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with azole antifungals, terbinafine has a different mechanism—squalene epoxidase inhibition—offering rapid fungicidal activity. It is often preferred for dermatophyte infections due to its high efficacy and lower rates of resistance, though choice of therapy should be individualized by the clinician.

Lamisil At should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from excess moisture, direct sunlight, and heat sources to maintain stability and potency.

Apply a thin layer of the cream to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands before and after application to avoid accidental contact with eyes or mucous membranes.

Although rare, serious adverse reactions can include severe allergic responses such as swelling, hives, difficulty breathing, or a widespread skin rash like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Lamisil At should be avoided in individuals with known hypersensitivity to terbinafine or any component of the formulation. It is also not recommended for children under two years of age unless specifically prescribed, and patients with extensive skin damage or severe eczema should consult a clinician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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