Product image of Lamisil Dermgel (Terbinafine) supplied by GNH India

Lamisil Dermgel

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Dermgel (Terbinafine)

Terbinafine, the active ingredient in Lamisil Dermgel, is an allylamine antifungal presented as a gel for topical use. It treats superficial fungal infections of the skin, such as athlete's foot, ringworm, jock itch, and beard area infections in patients as directed by a healthcare professional.

GNH India supplies Lamisil Dermgel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is used to treat superficial fungal infections of the skin.

  • Tinea pedis: reduces symptoms and eliminates the dermatophyte causing athlete's foot.
  • Tinea corporis: clears the ring‑shaped rash and eradicates the causative fungus.
  • Tinea cruris: relieves itching and resolves the fungal infection of the groin area.
  • Tinea barbae: treats fungal infection of the beard region, promoting healing of affected skin.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. By blocking this pathway, the drug causes accumulation of squalene and depletion of ergosterol, disrupting fungal cell membrane integrity and leading to cell death. The selective action on fungal cells limits impact on human cells, providing effective topical antifungal activity.

Side Effects

Common side effects are generally mild and localized to the application site.

Common Side Effects

  • Burning sensation: transient feeling of heat at the site of application.
  • Itching: mild pruritus that may occur during treatment.
  • Redness: localized erythema around the treated area.
  • Dryness: skin may become slightly dry or flaky.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, rash, or difficulty breathing.
  • Contact dermatitis: intense irritation or blistering of the skin.
  • Systemic absorption symptoms: rare cases of liver enzyme elevation.
  • Persistent ulceration: non‑healing sores at the application site.
  • Phototoxicity: heightened skin sensitivity to sunlight.

Precautions & Warnings

Before using Lamisil Dermgel, consider the following precautions.

  • Allergy assessment: avoid if you have known hypersensitivity to terbinafine or formulation excipients.
  • Open wounds: do not apply on broken skin or extensive lesions.
  • Pediatric use: follow prescriber guidance for children; safety data are limited.
  • Pregnancy and lactation: discuss risks with a healthcare professional before use.
  • Concomitant antifungal therapy: inform the prescriber of any other antifungal treatments.
  • Store below 25°C: keep in the original tube, protect from moisture and heat.

Avoid Interactions

Terbinafine topical gel may interact with other agents applied to the skin or systemic antifungals.

Major Interactions (Avoid)

  • Oral terbinafine: concurrent use can increase systemic exposure and risk of toxicity.
  • Systemic azole antifungals: may lead to additive hepatic effects.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Alcohol‑based skin products: can increase local irritation.
  • Other topical medications: assess for potential increased absorption or irritation.

Frequently Asked Questions

Lamisil Dermgel is prescribed for superficial fungal skin infections, including athlete's foot (tinea pedis), ringworm of the body (tinea corporis), jock itch (tinea cruris), and fungal infections of the beard area (tinea barbae). It works by eliminating the dermatophyte responsible for these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. This inhibition leads to a buildup of squalene and a shortage of ergosterol, causing the fungal cell membrane to become defective and the fungus to die.

The dosage of Lamisil Dermgel is determined by the prescribing healthcare professional based on the infection type, severity, and patient characteristics. The prescriber will provide specific instructions on the amount of gel to apply and the frequency of application.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Dermgel.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details, and any required import documentation.

Compared with azole topical agents, terbinafine has a different mechanism of action, targeting squalene epoxidase rather than lanosterol 14‑α‑demethylase. This can result in faster clinical cure rates for dermatophyte infections and a lower potential for drug‑drug interactions when used alone.

Lamisil Dermgel should be stored below 25 °C in its original container, protected from moisture, direct sunlight, and excessive heat. Keeping the gel in a cool, dry place helps maintain its stability and effectiveness.

The gel is applied topically to clean, dry skin in the affected area. A thin layer is spread over the lesion and surrounding skin as directed by the prescriber, usually once or twice daily, and the area is left uncovered unless otherwise instructed.

Serious risks, though rare, include severe allergic reactions such as swelling, rash, or difficulty breathing, and contact dermatitis that may cause blistering or ulceration. Any signs of systemic toxicity, such as liver enzyme changes, should be reported to a healthcare professional promptly.

Individuals with known hypersensitivity to terbinafine, its gel base, or any excipients should avoid using Lamisil Dermgel. It should also be avoided on extensive broken skin, open wounds, or in patients where a prescriber determines the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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