Product image of Lamisil Dermgel (Terbinafine) supplied by GNH India

Lamisil Dermgel

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Dermgel (Terbinafine)

Terbinafine, the active ingredient in Lamisil Dermgel, is a allylamine antifungal presented as a gel for topical use. It treats fungal skin infections such as athlete’s foot, ringworm, and nail fungus in both adults and children.

GNH India supplies Lamisil Dermgel as a licensed, GDP‑compliant international pharmaceutical supplier, meeting stringent EU quality standards and serving hospitals, pharmacies and clinics worldwide through a robust logistics platform that ensures timely, temperature‑controlled delivery and compliance with all applicable regulatory requirements across multiple regions.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is used to treat superficial fungal infections of the skin and nails.

  • Tinea pedis: relieves itching and clears fungal infection of the feet.
  • Tinea corporis: eliminates ring‑shaped lesions on the body.
  • Tinea cruris: treats fungal infection of the groin area.
  • Tinea unguium: improves appearance of infected nails.
  • Ringworm: eradicates dermatophyte infection on skin surfaces.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By blocking ergosterol production, the drug causes accumulation of toxic squalene and disrupts membrane integrity, leading to fungal cell death without affecting human cells. The selective inhibition is concentration‑dependent and results in a fungicidal effect after prolonged exposure.

Side Effects

Topical application of Lamisil Dermgel may be associated with local and, rarely, systemic adverse reactions.

Common Side Effects

  • Application site irritation: mild redness or itching at the site.
  • Burning sensation: transient warmth after application.
  • Dryness: skin may become dry or flaky.
  • Pruritus: occasional itching unrelated to infection.

Serious or Rare Side Effects

  • Allergic contact dermatitis: severe rash, swelling, or blistering.
  • Systemic hypersensitivity: urticaria, angioedema, or anaphylactic signs.
  • Hepatic effects: rare elevation of liver enzymes with extensive use.

Precautions & Warnings

Before using Lamisil Dermgel, consider the following precautions to ensure safe and effective therapy.

  • Pregnancy: consult a healthcare professional before application.
  • Breastfeeding: discuss potential risks with a physician.
  • Age restrictions: safety in children under two years has not been established.
  • Liver disease: use with caution and monitor hepatic function if extensive skin area is treated.
  • Concomitant medications: inform the prescriber of all topical or systemic drugs being used.
  • Store at room temperature: keep the gel in its original container, protect from moisture and direct sunlight.

Avoid Interactions

Lamisil Dermgel may interact with certain systemic and topical agents; awareness of these interactions helps minimize adverse outcomes.

Major Interactions (Avoid)

  • Systemic antifungals (e.g., itraconazole, fluconazole): may increase systemic terbinafine exposure.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): can alter terbinafine metabolism.
  • Alcohol: excessive intake may heighten risk of liver toxicity.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask local irritation or infection signs.
  • Other topical agents (e.g., salicylic acid): may increase skin irritation.
  • Warfarin: extensive application may affect INR, requiring monitoring.

Frequently Asked Questions

Lamisil Dermgel is indicated for the topical treatment of superficial fungal infections such as athlete’s foot (tinea pedis), body ringworm (tinea corporis), groin infection (tinea cruris), nail fungus (tinea unguium), and other dermatophyte‑related skin conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. Inhibiting this pathway leads to toxic squalene buildup and loss of membrane integrity, ultimately killing the fungus.

The prescribed amount of Lamisil Dermgel is set by the treating clinician based on the type, severity, and surface area of the infection, as well as patient age and any relevant medical conditions. No universal dosing schedule is provided here.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole‑based topicals, terbinafine has a fungicidal mechanism and often requires a shorter treatment duration for dermatophyte infections. It is generally well‑tolerated, but choice of therapy should consider infection type, patient history, and potential drug interactions.

Store Lamisil Dermgel at room temperature, preferably below 25 °C. Keep the tube tightly closed in its original packaging, protect it from moisture, direct sunlight and extreme heat to maintain product stability.

Clean and dry the affected area before use. Apply a thin layer of the gel to the lesion and surrounding skin, gently rub it in, and wash hands after application. Follow the prescriber’s instructions regarding frequency and duration of treatment.

Although uncommon, serious adverse reactions can include severe allergic contact dermatitis, systemic hypersensitivity (e.g., urticaria, angioedema), and rare hepatic effects such as elevated liver enzymes, especially with extensive or prolonged use.

Individuals with a known hypersensitivity to terbinafine or any component of the gel should avoid it. Patients with severe liver disease, or children under two years of age (unless specifically prescribed), should not use the product without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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