Product image of Lamisil Dermgel (Terbinafine) supplied by GNH India

Lamisil Dermgel

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Dermgel (Terbinafine)

Terbinafine, the active ingredient in Lamisil Dermgel, is an allylamine antifungal presented as a 1% gel for topical use. It treats fungal skin infections such as athlete's foot, ringworm and jock itch in adults and children.

GNH India supplies Lamisil Dermgel as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Terbinafine is used to treat superficial fungal infections of the skin.

  • Tinea pedis: reduces fungal growth and clears symptoms of athlete's foot.
  • Tinea corporis: eliminates the causative dermatophytes and resolves ringworm lesions.
  • Tinea cruris: improves itching and erythema associated with jock itch.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. By blocking this pathway, the drug causes accumulation of squalene and depletion of ergosterol, leading to disruption of the fungal cell membrane and ultimately cell death.

Side Effects

Common Side Effects

  • Application site itching or burning.
  • Redness or erythema at the site of application.
  • Dryness or scaling of the skin.
  • Mild irritation or stinging sensation.

Serious or Rare Side Effects

  • Severe allergic reaction such as angioedema or anaphylaxis.
  • Contact dermatitis with extensive blistering.
  • Systemic effects like liver enzyme elevation (rare with topical use).

Precautions & Warnings

Before using Lamisil Dermgel, consider the following precautions.

  • Pregnancy: safety not established; avoid unless benefits outweigh risks.
  • Breastfeeding: unknown; assess potential risk to infant.
  • Age: use in children only as directed by a healthcare professional.
  • Open wounds: do not apply on extensive skin damage or broken skin.
  • Concomitant topical agents: monitor for increased irritation when used with other creams.
  • Store at room temperature: keep in the original tube, protect from moisture and heat.

Avoid Interactions

Terbinafine gel has limited systemic absorption, but be aware of potential interactions.

Major Interactions (Avoid)

  • Concurrent oral terbinafine: may increase total terbinafine exposure.
  • Strong systemic CYP450 inhibitors: avoid simultaneous systemic use.

Moderate Interactions (Monitor Closely)

  • Other topical irritants (e.g., salicylic acid): may enhance skin irritation.
  • Topical corticosteroids: may reduce antifungal efficacy.
  • Alcohol-based hand sanitizers: could affect gel absorption.

Frequently Asked Questions

Lamisil Dermgel is prescribed to treat superficial fungal skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). The gel delivers terbinafine directly to the affected area to eradicate the dermatophyte organisms causing the infection.

Terbinafine inhibits the fungal enzyme squalene epoxidase, which is essential for ergosterol synthesis. Blocking this step leads to a buildup of squalene and a shortage of ergosterol, compromising the fungal cell membrane and resulting in fungal cell death.

The prescribed amount of Lamisil Dermgel is determined by the treating clinician based on the infection type, severity, and patient characteristics. The product is applied as a thin layer to the affected skin once daily for the duration specified by the prescriber.

Safety data for topical terbinafine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole creams, terbinafine has a different mechanism—blocking squalene epoxidase—and often achieves faster clinical cure rates for dermatophyte infections. It is generally well‑tolerated and requires once‑daily application, whereas some alternatives may need multiple daily doses.

Store Lamisil Dermgel at room temperature, below 25 °C. Keep the tube in its original packaging, protect it from moisture and direct heat, and ensure the cap is tightly closed to maintain product stability.

Clean and dry the affected skin area before use. Apply a thin layer of the gel to the lesion and a small margin of surrounding skin, gently rub it in, and wash hands after application. Follow the prescriber’s instructions regarding frequency and treatment duration.

While rare, serious adverse reactions can include severe allergic responses such as angioedema or anaphylaxis, extensive contact dermatitis, and, in exceptional cases, systemic effects like liver enzyme elevation. Patients should seek immediate medical attention if they experience signs of a serious reaction.

Individuals with known hypersensitivity to terbinafine or any component of the gel should avoid its use. It is also contraindicated on extensive broken skin, large areas of damaged epidermis, or when systemic terbinafine therapy is already being administered.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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