Product image of Lamisil Dermgel (Terbinafine) supplied by GNH India

Lamisil Dermgel

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Dermgel (Terbinafine)

Terbinafine, the active ingredient in Lamisil Dermgel, is an allylamine antifungal presented as a gel for cutaneous use. It treats superficial dermatophyte infections such as athlete's foot, ringworm and jock itch in both adults and children, helping to clear skin lesions and relieve associated symptoms.
GNH India supplies Lamisil Dermgel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Terbinafine is an allylamine antifungal used to treat superficial dermatophyte infections of the skin.

  • Tinea pedis: relieves itching, scaling and erythema caused by athlete's foot.
  • Tinea corporis: clears ring‑shaped lesions and reduces inflammation.
  • Tinea cruris: diminishes rash and discomfort in the groin area.
  • Other superficial dermatophyte infections: eliminates fungal growth on the skin surface.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This disruption leads to accumulation of toxic squalene and depletion of ergosterol, a key component of fungal cell membranes, resulting in loss of membrane integrity and fungal cell death.

Side Effects

Common Side Effects

  • Local irritation: mild burning or stinging at the application site.
  • Itching: transient pruritus after gel use.
  • Redness: erythema around the treated area.
  • Dry skin: occasional flaking or dryness.
  • Mild rash: transient localized rash.

Serious or Rare Side Effects

  • Severe allergic reaction: angioedema or anaphylaxis.
  • Contact dermatitis: intense skin inflammation.
  • Stevens‑Johnson syndrome: rare but serious skin disorder.
  • Severe skin blistering: extensive bullae formation.
  • Systemic absorption effects: rare liver enzyme elevation.

Precautions & Warnings

Before using Lamisil Dermgel, consider the following precautions:

  • Apply to intact skin only: avoid broken or inflamed areas.
  • Avoid ocular contact: wash eyes thoroughly if exposure occurs.
  • Do not combine with other topical antifungals unless directed by a healthcare professional.
  • Use with caution in patients with known hepatic impairment.
  • Pregnant or breastfeeding women: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Terbinafine topical gel has limited systemic interactions, but the following should be considered.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine therapy: risk of cumulative exposure.
  • Use with topical products containing high alcohol content: may increase irritation.
  • Known hypersensitivity to allylamine class: avoid application.

Moderate Interactions (Monitor Closely)

  • Co‑application with topical corticosteroids: may mask local reactions.
  • Use under occlusive dressings: can increase percutaneous absorption.
  • Combination with other antifungal agents: monitor for increased local irritation.

Frequently Asked Questions

Lamisil Dermgel is a topical formulation of terbinafine indicated for the treatment of superficial dermatophyte infections such as athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It works by eliminating the fungi that cause these skin conditions, helping to clear lesions and relieve symptoms.

Terbinafine belongs to the allylamine class of antifungals. It blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. The resulting buildup of squalene and loss of ergosterol disrupts membrane integrity, leading to fungal cell death.

The specific dosing regimen for Lamisil Dermgel is determined by the prescribing healthcare professional based on the infection type, severity, and patient factors. Typically, the gel is applied once daily to the affected area for a prescribed number of weeks, but exact instructions should always follow the prescriber’s order.

Safety data for topical terbinafine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lamisil Dermgel. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Compared with azole antifungals, terbinafine has a different mechanism—blocking squalene epoxidase rather than inhibiting lanosterol 14α‑demethylase. This often results in a shorter treatment duration for dermatophyte infections. Terbinafine also tends to have a lower risk of drug‑drug interactions than many systemic azoles, though topical formulations are generally well tolerated.

Store Lamisil Dermgel at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and excessive heat. Ensure the container is tightly closed when not in use to maintain gel integrity.

Clean and dry the affected skin area before application. Apply a thin layer of the gel to the lesion and surrounding skin, gently rubbing it in until fully absorbed. Wash hands after use unless the hands are the treatment site. Follow the prescriber’s frequency and duration instructions.

While most reactions are mild, serious adverse events can include severe allergic reactions such as angioedema or anaphylaxis, Stevens‑Johnson syndrome, extensive skin blistering, and rare systemic effects like liver enzyme elevation. Any signs of severe rash, swelling, or systemic symptoms should prompt immediate medical attention.

Lamisil Dermgel should be avoided in individuals with known hypersensitivity to terbinafine, other allylamine antifungals, or any component of the formulation. It is also contraindicated on broken or severely inflamed skin, and caution is advised for patients with significant liver disease or those who are pregnant or breastfeeding without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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