Product image of Lamisil Once (Terbinafine) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Once (Terbinafine)

Terbinafine, the active ingredient in Lamisil Once, is a Allylamine antifungal presented as a unknown/unknown for topical use. It treats superficial dermatophyte infections such as athlete's foot, jock itch and ringworm in both adults and children.

GNH India supplies Lamisil Once as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is an allylamine antifungal used to treat superficial dermatophyte infections.

  • Tinea corporis: reduces fungal growth and clears the body rash.
  • Tinea cruris: eliminates the fungus causing jock itch and relieves itching.
  • Tinea pedis: clears athlete's foot by eradicating the causative dermatophytes.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This disruption leads to accumulation of toxic squalene and depletion of ergosterol, a vital component of fungal cell membranes, resulting in loss of membrane integrity and fungal cell death.

Side Effects

Terbinafine may cause local skin reactions when applied topically.

Common Side Effects

  • Itching: mild to moderate sensation at the application site.
  • Redness: localized erythema.
  • Burning: transient heat sensation.
  • Scaling: flaking of the treated skin.
  • Dryness: reduced skin moisture.
  • Irritation: mild discomfort or stinging.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Contact dermatitis: intense rash or blistering.
  • Urticaria: widespread hives.
  • Stevens-Johnson syndrome: rare severe skin disorder.
  • Swelling: pronounced edema of the treated area.
  • Blister formation: fluid‑filled lesions.

Precautions & Warnings

Before using Lamisil Once, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before application.
  • Breastfeeding: discuss potential risks with a doctor.
  • Age: follow pediatric guidance for children.
  • Skin condition: avoid use on broken or inflamed skin.
  • Allergy: discontinue if a severe reaction occurs.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine topical may interact with other medications or products.

Major Interactions (Avoid)

  • Systemic terbinafine: concurrent systemic therapy may increase overall exposure.
  • Strong CYP2D6 inhibitors: may raise terbinafine levels and risk systemic effects.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Other topical agents (e.g., salicylic acid): risk of increased skin irritation.
  • Alcohol‑based cleansers: may enhance local irritation when used together.

Frequently Asked Questions

Lamisil Once is a topical formulation of terbinafine indicated for the treatment of superficial dermatophyte infections such as tinea corporis (ringworm of the body), tinea cruris (jock itch) and tinea pedis (athlete's foot). It works by eliminating the fungi that cause these skin conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. The resulting buildup of squalene and loss of ergosterol compromise membrane integrity, leading to fungal cell death and clearance of the infection.

The specific dosing regimen for Lamisil Once is determined by the prescribing healthcare professional based on the infection type, severity, patient age and skin condition. Patients should follow the instructions provided on the prescription label and by their clinician.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Once.

To request Lamisil Once, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Once (terbinafine) belongs to the allylamine class, which directly inhibits squalene epoxidase, offering a rapid fungicidal effect. Compared with azole antifungals that target lanosterol 14α‑demethylase, terbinafine often requires a shorter treatment duration for superficial infections and has a distinct safety profile.

Lamisil Once should be stored at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

The cream or solution is applied thinly to the affected skin area once daily, or as directed by the prescriber, after washing and drying the skin. The treated area should be covered with a clean dressing if recommended, and the medication should be used for the full course prescribed.

While most reactions are mild, serious risks include severe allergic responses such as anaphylaxis, extensive contact dermatitis, blistering, or rare conditions like Stevens‑Johnson syndrome. Any signs of widespread rash, swelling, or difficulty breathing require immediate medical attention.

Individuals with known hypersensitivity to terbinafine or any component of the formulation should avoid using Lamisil Once. It is also contraindicated on severely damaged or inflamed skin, and patients should consult a clinician before use if they have liver disease, are pregnant, or are breastfeeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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