Product image of Lamisil Once (Terbinafine) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Once (Terbinafine)

Terbinafine, the active ingredient in Lamisil Once, is an allylamine presented as a topical formulation for skin application. It works by inhibiting fungal squalene epoxidase, thereby disrupting ergosterol synthesis and halting the growth of dermatophytes. The product is indicated for the treatment of superficial fungal infections of the skin and nails in both adults and children.

GNH India supplies Lamisil Once as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑assured shipments that meet EU regulatory standards.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

  • Terbinafine is an allylamine antifungal that targets dermatophyte infections of the skin.
  • Athlete's foot (tinea pedis): clears infection and relieves itching and scaling.
  • Ringworm (tinea corporis): eliminates fungal growth and promotes lesion resolution.
  • Jock itch (tinea cruris): reduces redness and clears the affected area.
  • Nail fungus (tinea unguium) – superficial involvement: improves nail appearance and reduces fungal load.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By blocking this pathway, intracellular squalene accumulates to toxic levels while ergosterol depletion compromises membrane integrity, leading to fungal cell death. The selective inhibition spares human cells because the target enzyme is absent in mammalian pathways.

Side Effects

Topical terbinafine may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Burning or stinging at the application site
  • Redness or erythema
  • Itching or pruritus

Serious or Rare Side Effects

  • Severe allergic reaction such as angioedema or anaphylaxis
  • Contact dermatitis with blistering or swelling
  • Systemic hypersensitivity presenting as fever, malaise, or widespread rash

Precautions & Warnings

  • When using Lamisil Once, consider the following safety measures to minimize risk and ensure effective therapy.
  • Avoid use on broken or inflamed skin: apply only to intact epidermis.
  • Do not cover treated area with occlusive dressings unless directed: may increase absorption.
  • Limit treatment duration to the prescribed period: prolonged use can increase irritation.
  • Discontinue if severe irritation or allergic reaction occurs: seek medical advice.
  • Store at room temperature (below 25 °C): keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with other topical agents or systemic medications that affect liver enzymes or skin integrity.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals containing azoles: may increase local irritation.
  • Systemic terbinafine therapy: combined use can raise systemic exposure and risk of hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids applied to the same site: may mask signs of irritation.
  • Alcohol‑based skin products: may enhance absorption and cause burning.

Frequently Asked Questions

Lamisil Once is a topical antifungal medication containing terbinafine. It is used to treat superficial fungal infections of the skin such as athlete's foot, ringworm and jock itch, and can also be applied to mild cases of nail fungus affecting the nail surface.

Terbinafine inhibits the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. Blocking this step leads to toxic squalene buildup and loss of membrane integrity, ultimately killing the fungus.

The prescribed dose and duration are determined by a qualified healthcare professional based on the type and severity of the infection. Patients should follow the prescriber’s instructions and not alter the amount or frequency of application without medical advice.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Once (terbinafine) belongs to the allylamine class, which directly inhibits squalene epoxidase. This mechanism differs from azole antifungals that block lanosterol 14α‑demethylase. Allylamines often achieve faster fungal clearance and have a lower risk of drug‑enzyme interactions compared with many azoles.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until it disappears, and wash your hands after each application unless the hands are the treatment site.

Although rare, serious adverse reactions can include severe allergic responses such as angioedema, anaphylaxis, or extensive contact dermatitis. If you experience swelling of the face, throat, difficulty breathing, or widespread rash, discontinue use immediately and seek emergency medical care.

Individuals with known hypersensitivity to terbinafine, other allylamines, or any component of the formulation should avoid using Lamisil Once. It should also be avoided on severely damaged, inflamed or infected skin unless specifically instructed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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