Product image of Lamisil Once (Terbinafine) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Once (Terbinafine)

Terbinafine, the active ingredient in Lamisil Once, is an allylamine antifungal presented as a topical formulation for topical use. It treats dermatophyte skin infections such as athlete's foot, ringworm and jock itch in both adults and children.

GNH India supplies Lamisil Once as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil Once is an allylamine antifungal used to treat common dermatophyte infections of the skin.

  • Athlete's foot (tinea pedis): Reduces fungal growth, relieving itching, scaling and redness.
  • Ringworm (tinea corporis): Clears the infection and promotes healing of the affected skin.
  • Jock itch (tinea cruris): Eliminates the fungus and eases discomfort and irritation.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, which is essential for converting squalene to ergosterol. This disruption impairs ergosterol synthesis, a critical component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death without affecting human cells.

Side Effects

Topical terbinafine may cause local skin reactions, though most users tolerate it well.

Common Side Effects

  • Burning sensation at the application site
  • Itching or pruritus
  • Redness or erythema
  • Dryness or flaking of the skin
  • Mild rash
  • Stinging feeling

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis)
  • Contact dermatitis with swelling
  • Urticaria (hives)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis (very rare)
  • Systemic absorption leading to liver enzyme elevation (rare with extensive use)
  • Persistent skin ulceration or necrosis.

Precautions & Warnings

Before using Lamisil Once, consider the following safety measures.

  • Apply to intact skin only: Avoid broken or inflamed areas.
  • Avoid mucous membranes: Do not use on eyes, mouth or genital mucosa.
  • Limit surface area: Do not treat large body areas without medical advice.
  • Discontinue if severe irritation occurs: Seek professional evaluation.
  • Pregnancy and breastfeeding: Consult a healthcare professional before use.
  • Store at room temperature: Keep in the original container, protect from moisture and light.

Avoid Interactions

Topical terbinafine has limited systemic interactions, but certain co‑applications may affect safety.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals containing the same active ingredient.
  • Application together with strong topical corticosteroids that may increase skin irritation.

Moderate Interactions (Monitor Closely)

  • Use with other skin irritants (e.g., chemical peels) may exacerbate local reactions.
  • Co‑application with sunscreen or moisturizers containing alcohol may increase burning sensation.
  • Systemic terbinafine therapy: May increase overall terbinafine exposure; coordinate with a clinician.

Frequently Asked Questions

Lamisil Once is a topical antifungal medication indicated for the treatment of common dermatophyte skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It works by eliminating the fungus that causes these conditions, helping to relieve symptoms like itching, redness and scaling.

Terbinafine belongs to the allylamine class of antifungals. It blocks the fungal enzyme squalene epoxidase, which is required for the synthesis of ergosterol, an essential component of fungal cell membranes. By disrupting ergosterol production, terbinafine causes toxic buildup of squalene and leads to fungal cell death.

The specific dose and frequency of Lamisil Once are determined by the prescribing healthcare professional based on the infection’s location, severity and patient factors. Patients should follow the prescriber’s instructions and the product label for proper application.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Once.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lamisil Once. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Once (topical terbinafine) offers a targeted approach for dermatophyte skin infections with a mechanism that differs from azole antifungals, which inhibit a later step in ergosterol synthesis. Terbinafine often requires shorter treatment durations and may be effective against strains resistant to azoles, but choice of therapy should be guided by clinical assessment.

Lamisil Once should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Apply a thin layer of Lamisil Once to the affected skin area once daily, or as directed by a healthcare professional. Gently rub the medication into clean, dry skin, and wash your hands after application unless the hands are being treated.

While uncommon, serious adverse reactions can include severe allergic responses such as angioedema, anaphylaxis, or rare skin conditions like Stevens‑Johnson syndrome. If you experience swelling, difficulty breathing, widespread rash, or blistering, discontinue use immediately and seek medical attention.

Lamisil Once should not be used on broken, inflamed or infected skin without medical advice, nor on mucous membranes such as the eyes, mouth or genital area. Individuals with known hypersensitivity to terbinafine or any component of the formulation should avoid using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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