Product image of Lamisil Once (Terbinafine) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Once (Terbinafine)

Terbinafine, the active ingredient in Lamisil Once, is an allylamine antifungal presented as a topical formulation for skin application. It treats dermatophyte infections such as athlete’s foot, ringworm and jock itch in adults and children.

GNH India supplies Lamisil Once as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Lamisil Once is an allylamine antifungal used to treat common dermatophyte skin infections.

  • Tinea pedis: alleviates itching, scaling and redness caused by athlete’s foot.
  • Tinea corporis: clears ring-shaped lesions on the body.
  • Tinea cruris: resolves itching and erythema in the groin area.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to accumulation of toxic squalene and loss of membrane integrity, ultimately causing fungal cell death.

Side Effects

Topical terbinafine may cause local and systemic adverse reactions.

Common Side Effects

  • Burning sensation at the application site
  • Itching
  • Redness
  • Scaling
  • Dryness
  • Mild irritation

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis)
  • Contact dermatitis
  • Systemic hepatotoxicity (rare with extensive use)
  • Stevens‑Johnson syndrome (very rare)

Precautions & Warnings

Before using Lamisil Once, consider the following safety measures.

  • Confirm diagnosis: ensure the infection is caused by dermatophytes before use.
  • Avoid on broken skin: do not apply to open wounds or inflamed areas.
  • Concurrent topical antifungals: do not combine with other antifungal creams unless directed.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Monitor for systemic symptoms: report signs of liver dysfunction or severe skin reactions.
  • Store at room temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Terbinafine may interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Oral terbinafine: concurrent systemic use may increase risk of hepatotoxicity.
  • CYP2D6 inhibitors: may affect systemic absorption of terbinafine.

Moderate Interactions (Monitor Closely)

  • Alcohol: excessive intake may heighten liver risk if systemic absorption occurs.
  • Other topical irritants: may increase local skin irritation.
  • Phototherapy: may enhance skin sensitivity.

Frequently Asked Questions

Lamisil Once is indicated for the topical treatment of dermatophyte skin infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It helps relieve itching, scaling and redness associated with these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, a key component of fungal cell membranes. This disruption leads to toxic squalene buildup and loss of membrane integrity, causing fungal cell death.

The dosage and duration of Lamisil Once are determined by the prescribing healthcare professional based on the type and severity of the infection. Patients should follow the prescriber’s instructions and the product label.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Once.

To request Lamisil Once, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Once (terbinafine) belongs to the allylamine class, which differs from azole antifungals that inhibit lanosterol 14‑α‑demethylase. Terbinafine often requires a shorter treatment course and has a favorable efficacy profile for dermatophyte infections, though choice of therapy depends on the specific infection and patient factors.

Store Lamisil Once at room temperature, below 25 °C (77 °F). Keep the product in its original container, protect it from moisture and direct heat, and ensure the cap is tightly closed to maintain stability.

Lamisil Once is applied topically to the affected skin area once daily, or as directed by a healthcare professional. The skin should be clean and dry before application, and the treated area should be covered with a thin film of the product.

Serious but rare risks include severe allergic reactions such as angioedema or anaphylaxis, contact dermatitis, systemic hepatotoxicity, and Stevens‑Johnson syndrome. Patients should discontinue use and seek medical attention if they experience signs of a severe reaction.

Lamisil Once should not be used by individuals with a known hypersensitivity to terbinafine or any component of the formulation. It is also contraindicated on broken or severely inflamed skin unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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