Product image of Lamisil Once (Terbinafine) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Once (Terbinafine)

Terbinafine, the active ingredient in Lamisil Once, is an allylamine antifungal presented as a topical formulation for topical use. It treats dermatophyte skin infections such as athlete's foot, ringworm and jock itch in adults and children.
GNH India supplies Lamisil Once as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil Once is an allylamine antifungal used to treat superficial dermatophyte infections of the skin.

  • Tinea pedis (athlete's foot): reduces fungal growth and clears the infection.
  • Tinea corporis (ringworm): alleviates lesions and promotes skin healing.
  • Tinea cruris (jock itch): resolves itching, redness and rash associated with the infection.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, which blocks the conversion of squalene to ergosterol. This interruption prevents synthesis of ergosterol, an essential component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death.

Side Effects

Terbinafine may cause local and systemic reactions when applied to the skin.

Common Side Effects

  • Mild skin irritation at the application site.
  • Itching or burning sensation.
  • Redness or erythema.
  • Dryness or peeling of the treated area.
  • Slight itching elsewhere on the body.

Serious or Rare Side Effects

  • Severe allergic reaction (hives, swelling, difficulty breathing).
  • Contact dermatitis with blistering.
  • Persistent rash or ulceration.
  • Unexplained fever.
  • Hepatotoxicity (rare, indicated by jaundice or abnormal liver tests).

Precautions & Warnings

Before using Lamisil Once, consider the following precautions:

  • Avoid application to broken or inflamed skin: limit use to intact areas.
  • Do not use on extensive body surface: follow prescriber guidance for area size.
  • Monitor for signs of allergic reaction: discontinue if severe rash or swelling occurs.
  • Pregnant or breastfeeding individuals should consult a healthcare professional before use.
  • Keep out of reach of children: accidental ingestion may cause systemic effects.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with other substances applied to the skin or absorbed systemically.

Major Interactions (Avoid)

  • Concurrent use of other topical antifungals containing azoles: may increase irritation risk.
  • Systemic terbinafine therapy: avoid duplicate topical exposure.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids applied to the same area: may reduce antifungal efficacy.
  • Products containing alcohol or harsh solvents: may enhance skin irritation.
  • Use with occlusive dressings: may increase drug absorption and local side effects.

Frequently Asked Questions

Lamisil Once is indicated for the topical treatment of superficial dermatophyte infections of the skin, including athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It helps to eliminate the fungus and relieve associated symptoms.

Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking ergosterol synthesis in the cell membrane. This leads to accumulation of toxic squalene and loss of membrane integrity, causing fungal cell death and clearing the infection.

The dosage regimen for Lamisil Once is determined by the prescribing healthcare professional based on the type and extent of the infection. Patients should follow the prescriber's instructions and apply the product as directed.

Safety of topical terbinafine during pregnancy or lactation has not been fully established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Once.

To request Lamisil Once, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lamisil Once (terbinafine) belongs to the allylamine class, which acts by inhibiting squalene epoxidase, whereas azole antifungals inhibit lanosterol 14α‑demethylase. Terbinafine often provides rapid fungicidal activity and is effective against dermatophytes, making it a preferred option for many superficial skin infections.

Lamisil Once should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a cool, dry place helps maintain its stability and efficacy.

The product is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually once daily, and gently rubbed in until fully absorbed. Patients should follow the specific instructions provided by their prescriber.

Serious risks include severe allergic reactions such as hives, swelling, or difficulty breathing, and rare cases of hepatotoxicity. If any signs of a serious reaction occur, the product should be discontinued and medical attention sought immediately.

Individuals with known hypersensitivity to terbinafine or any component of the formulation should avoid using Lamisil Once. It is also contraindicated on broken, inflamed, or extensively damaged skin, and should be used with caution in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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