Product image of Lamisil Once (Terbinafine Hydrochloride) supplied by GNH India

Lamisil Once

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil Once (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil Once, is an allylamine antifungal presented as a topical formulation for skin use. It treats superficial dermatophyte infections such as athlete’s foot, ringworm and jock itch in adults and children.

GNH India supplies Lamisil Once as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil Once (terbinafine) is used to treat superficial fungal infections caused by dermatophytes.

  • Tinea corporis: clears ring‑shaped skin lesions caused by dermatophytes.
  • Tinea pedis: resolves itching, scaling and redness of athlete’s foot.
  • Tinea cruris: alleviates jock itch symptoms and eradicates the underlying fungus.
  • Superficial dermatophyte infections: eliminates fungal colonisation on the skin surface.

How It Works

  • Terbinafine Hydrochloride inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This disruption impairs ergosterol synthesis, a key component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell membrane damage and cell death.

Side Effects

Common Side Effects

  • Itching at the application site.
  • Burning sensation during or after application.
  • Redness or erythema of the treated skin.
  • Dryness or flaking of the skin.
  • Mild irritation or stinging.
  • Scaling or peeling of the skin.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Contact dermatitis with extensive swelling.
  • Blistering or bullous eruptions.
  • Urticaria (hives).
  • Angioedema of the face or lips.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis (very rare).

Precautions & Warnings

Before using Lamisil Once, consider the following precautions.

  • Apply to intact skin only: avoid broken or inflamed areas.
  • Avoid contact with eyes: rinse thoroughly if accidental exposure occurs.
  • Do not combine with other topical antifungals unless directed by a healthcare professional.
  • Discontinue use if severe irritation or allergic reaction develops: seek medical advice.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Terbinafine topical has limited systemic interactions, but awareness of concomitant therapies is important.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine therapy: risk of cumulative systemic exposure.
  • Use with other topical irritants (e.g., corticosteroids) without medical guidance.

Moderate Interactions (Monitor Closely)

  • Co‑application with other antifungal creams may reduce overall efficacy.
  • Use with occlusive dressings may increase percutaneous absorption.
  • Patients on warfarin: monitor INR if systemic absorption is suspected.

Frequently Asked Questions

Lamisil Once is indicated for the topical treatment of superficial dermatophyte infections such as tinea corporis (ringworm), tinea pedis (athlete’s foot) and tinea cruris (jock itch). It works by eliminating the fungal organisms that cause these skin conditions.

Terbinafine Hydrochloride blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to accumulation of toxic squalene and disruption of the membrane, causing fungal cell death.

The specific dose and duration of Lamisil Once are determined by the prescribing healthcare professional based on the infection type, severity, patient age and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for topical terbinafine during pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Lamisil Once to pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Once belongs to the allylamine class, which acts on fungal squalene epoxidase, whereas many alternatives such as azoles inhibit lanosterol 14α‑demethylase. Allylamines often achieve rapid fungicidal activity and are effective for dermatophyte infections, offering a different mechanism that can be useful when azole resistance is a concern.

Lamisil Once should be stored at room temperature, below 25 °C, in its original container. Keep the product away from excess moisture and direct sunlight to maintain its stability and potency.

Apply a thin layer of the cream or gel to the affected skin area once daily, or as directed by the prescriber. Gently rub it in until it disappears, and wash hands before and after application to avoid spreading the medication to other sites.

While uncommon, serious adverse reactions can include severe allergic responses such as anaphylaxis, extensive swelling, blistering, or rare conditions like Stevens‑Johnson syndrome. Patients should discontinue use and seek immediate medical attention if they notice any of these symptoms.

Lamisil Once should not be used on broken, inflamed or infected skin unless specifically advised by a healthcare professional. Individuals with a known hypersensitivity to terbinafine or any component of the formulation should avoid using the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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