Product image of Lamisil Singeldos (Terbinafine) supplied by GNH India

Lamisil Singeldos

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Singeldos (Terbinafine)

Terbinafine, the active ingredient in Lamisil Singeldos, is an allylamine antifungal presented as a topical formulation for cutaneous use. It treats dermatophyte infections of the skin and nails in adults and children as directed by a healthcare professional.

GNH India supplies Lamisil Singeldos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Products are shipped with appropriate documentation and temperature control where required, ensuring compliance with local regulations.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Terbinafine is indicated for the treatment of dermatophyte infections affecting the skin and nails.

  • Athlete's foot (tinea pedis): reduces fungal growth and relieves itching, scaling and redness.
  • Ringworm (tinea corporis): eliminates the causative fungus and promotes healing of skin lesions.
  • Jock itch (tinea cruris): clears infection and diminishes discomfort in the groin area.
  • Fungal nail infection (tinea unguium): improves nail appearance by inhibiting fungal proliferation.

How It Works

  • Terbinafine acts by inhibiting the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol, an essential component of fungal cell membranes. Blockade of this pathway leads to accumulation of toxic squalene within the cell and depletion of ergosterol, resulting in loss of membrane integrity and fungal cell death. Because human cells lack squalene epoxidase, the effect is selective for fungi, providing a high therapeutic index.

Side Effects

Topical terbinafine may cause local and, rarely, systemic adverse reactions.

Common Side Effects

  • Burning sensation at the site of application, usually mild and transient.
  • Itching or pruritus that may develop within the first few days of use.
  • Redness, erythema accompanied by slight swelling of the treated area.
  • Dryness, peeling or flaking of the skin where the cream is applied.

Serious or Rare Side Effects

  • Severe allergic reactions such as angioedema, swelling of lips, tongue or throat.
  • Contact dermatitis presenting with blistering, intense itching and rash spreading beyond the application site.
  • Generalized skin eruptions including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Rare systemic hepatotoxicity manifested by jaundice, abdominal pain or abnormal liver tests.

Precautions & Warnings

When using Lamisil Singeldos, certain precautions should be observed to ensure safety and effectiveness.

  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss potential risks with a physician, as drug may pass into milk.
  • Extensive skin damage: avoid application on open wounds, burns or severe dermatitis.
  • Large surface area: limit use to recommended area; excessive coverage may increase systemic absorption.
  • Concomitant systemic antifungals: inform the prescriber to monitor for possible drug interactions.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with other medicines; awareness of significant interactions helps prevent adverse effects.

Major Interactions (Avoid)

  • Co‑administration with systemic azole antifungals (e.g., itraconazole) can increase risk of hepatotoxicity.
  • Use together with strong CYP2D6 inhibitors (e.g., fluoxetine) may raise terbinafine plasma levels.
  • Concurrent warfarin therapy may enhance anticoagulant effect and bleeding risk.

Moderate Interactions (Monitor Closely)

  • Applying other topical agents (e.g., corticosteroids) may mask infection signs or increase irritation.
  • Use with other dermatologic preparations containing alcohol may cause local burning.

Frequently Asked Questions

Lamisil Singeldos is a topical antifungal medication containing terbinafine. It is employed to treat superficial fungal infections of the skin and nails caused by dermatophytes, such as athlete’s foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris) and, in some cases, fungal nail infections (tinea unguium). The product is applied directly to the affected area as directed by a healthcare professional.

Terbinafine works by inhibiting the fungal enzyme squalene epoxidase, which is essential for the synthesis of ergosterol, a key component of fungal cell membranes. Blocking this step leads to an accumulation of toxic squalene and depletion of ergosterol, compromising membrane integrity and causing fungal cell death. Human cells lack this enzyme, giving terbinafine a high degree of selectivity for fungal organisms.

The appropriate dose of Lamisil Singeldos is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and other clinical factors. The prescriber will specify the amount of product to apply, the frequency of application (often once or twice daily), and the duration of therapy, which typically ranges from one to several weeks.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Lamisil Singeldos. The prescriber may decide to avoid the medication or to monitor the patient closely, depending on the clinical situation.

To place an order for Lamisil Singeldos, visit the product page on the GNH India website (gnhindia.com) and submit an enquiry with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details and any necessary import documentation.

Lamisil Singeldos (terbinafine) belongs to the allylamine class of antifungals, which act by inhibiting squalene epoxidase, whereas azole antifungals such as clotrimazole or miconazole block lanosterol 14‑α‑demethylase. Terbinafine often requires a shorter treatment course and has a lower recurrence rate for dermatophyte infections, but individual response and tolerability may vary, making physician guidance essential when selecting therapy.

Lamisil Singeldos should be stored at room temperature, typically below 25 °C (77 °F). Keep the product in its original container, tightly closed, and protect it from moisture, direct sunlight and extreme heat. Do not freeze the medication. Follow any additional storage instructions on the label to maintain product stability and efficacy.

Lamisil Singeldos is applied directly to clean, dry skin or nails in the area affected by the fungal infection. The prescribed amount is spread thinly over the lesion and a small margin of surrounding healthy skin, usually once or twice daily as directed by the prescriber. Hands should be washed after application, and the treated area should be allowed to dry before covering with clothing or bandages.

Although most adverse reactions are mild and localized, serious risks can include severe allergic responses such as angioedema, generalized skin eruptions like Stevens‑Johnson syndrome, and, rarely, systemic hepatotoxicity resulting from significant absorption. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, fever, jaundice, or persistent abdominal discomfort while using the product.

Lamisil Singeldos should be avoided in individuals with a known hypersensitivity to terbinafine or any of the formulation excipients. It is also contraindicated on extensive open wounds, severe burns, or damaged skin where absorption may be increased. Patients with pre‑existing liver disease, pregnant or nursing women, and those taking interacting medications should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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