Product image of Lamisil (Terbinafine) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil (Terbinafine)

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for skin application. It works by inhibiting fungal cell membrane synthesis and is indicated for the treatment of common superficial fungal infections such as athlete’s foot, ringworm and jock itch in both adults and children.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all shipments and providing reliable logistics support.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Terbinafine is used to treat superficial fungal infections of the skin and nails.

  • Tinea pedis (athlete’s foot): clears infection and relieves itching on the feet.
  • Tinea corporis (ringworm): eliminates the fungal rash on the body.
  • Tinea cruris (jock itch): resolves irritation in the groin area.
  • Cutaneous fungal infections: treats a variety of dermatophyte skin infections.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts the formation of ergosterol, an essential component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death.

Side Effects

Terbinafine is generally well tolerated, but skin application can cause local reactions.

Common Side Effects

  • Burning sensation: mild to moderate discomfort at the application site.
  • Itching: transient pruritus around the treated area.
  • Redness: localized erythema.
  • Dryness: skin may become flaky or dry.
  • Scaling: slight flaking of the skin.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Contact dermatitis: intense rash or blistering.
  • Systemic absorption effects: rare liver enzyme elevation.
  • Persistent irritation: prolonged burning or pain.
  • Secondary infection: bacterial infection of the treated skin.

Precautions & Warnings

Before using Lamisil topical, consider the following safety measures.

  • Assess skin integrity: avoid application on broken or inflamed skin.
  • Allergy check: discontinue if signs of hypersensitivity appear.
  • Concomitant skin products: avoid using other topical agents on the same area.
  • Duration of therapy: follow prescriber’s recommended treatment length.
  • Pediatric use: ensure appropriate dosing for children as directed.
  • Store at room temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine topical has limited systemic absorption, but interactions may still occur.

Major Interactions (Avoid)

  • Oral terbinafine: concurrent use may increase systemic exposure.
  • Strong CYP2D6 inhibitors: could affect metabolism if systemic absorption occurs.

Moderate Interactions (Monitor Closely)

  • Other topical antifungals: risk of additive irritation.
  • Corticosteroid creams: may mask infection signs.
  • Alcohol-based products: could enhance skin irritation.

Frequently Asked Questions

Lamisil (terbinafine) is indicated for the topical treatment of superficial fungal infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris) and other cutaneous dermatophyte infections.

Terbinafine inhibits the fungal enzyme squalene epoxidase, disrupting ergosterol synthesis in the cell membrane. This leads to accumulation of squalene, loss of membrane integrity and ultimately fungal cell death.

The prescribed dose of Lamisil topical is determined by the treating healthcare professional based on the infection type, severity and patient characteristics. Patients should follow the prescriber’s instructions exactly.

Safety data for topical terbinafine in pregnancy and lactation are limited. Use should be considered only if the potential benefit outweighs any possible risk, and it is best to discuss use with a qualified healthcare provider.

To order Lamisil, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals, terbinafine has a different mechanism (squalene epoxidase inhibition) and often achieves faster clinical cure rates for dermatophyte infections. Choice of therapy depends on infection type, patient tolerance and prescriber preference.

Store Lamisil at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the cap is tightly closed when not in use.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily as directed by the prescriber, typically after washing and drying the skin. Continue treatment for the full course even if symptoms improve.

Serious risks, though rare, include severe allergic reactions such as swelling, hives or difficulty breathing, and contact dermatitis presenting as intense rash or blistering. Immediate medical attention is required if these occur.

Lamisil should not be used on patients with known hypersensitivity to terbinafine or any formulation components, on severely damaged or inflamed skin, and it is contraindicated in individuals where systemic terbinafine therapy is already prescribed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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