Product image of Lamisil (Terbinafine) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil (Terbinafine)

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for skin application. It penetrates the stratum corneum to reach the site of infection and is used to treat fungal infections of the skin, hair, and nails in both adults and children under medical supervision. Lamisil is indicated for common dermatophyte infections and is marketed in the European Union.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil is an allylamine antifungal indicated for dermatophyte infections of the skin, hair and nails.

  • Tinea pedis: reduces fungal infection of the feet, relieving itching, scaling and redness.
  • Tinea corporis: clears ring‑shaped lesions on the body, diminishing inflammation and spread.
  • Tinea cruris: treats fungal infection of the groin area, alleviating irritation and rash.
  • Tinea unguium (onychomycosis): improves nail appearance by eradicating the causative fungus.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, which blocks conversion of squalene to ergosterol. This leads to accumulation of toxic squalene and depletion of ergosterol, a key component of the fungal cell membrane. The disrupted membrane integrity results in fungal cell death, effectively clearing the infection at the site of application.

Side Effects

Topical terbinafine may cause local and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Burning sensation: transient warmth during use.
  • Dryness: peeling or flaking of treated skin.
  • Pruritus: occasional itching.
  • Erythema: mild redness.
  • Stinging: brief discomfort upon application.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare but serious skin blistering and detachment.
  • Liver enzyme elevation: systemic absorption may affect liver function.
  • Contact dermatitis: intense skin inflammation.
  • Anaphylaxis: life‑threatening hypersensitivity response.

Precautions & Warnings

When using Lamisil topical, consider the following precautions to ensure safe and effective treatment.

  • Avoid application on broken skin: may increase systemic absorption.
  • Do not use with other topical antifungals without medical advice: risk of irritation.
  • Limit use to prescribed area: avoid eyes, mucous membranes, and genitalia unless directed.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Terbinafine topical can interact with certain systemic and topical agents; awareness of these interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent oral terbinafine therapy: may increase systemic exposure and risk of toxicity.
  • Use with potent CYP2D6 inhibitors: can alter terbinafine metabolism.
  • Co‑administration with other topical antifungals without guidance: risk of irritation.

Moderate Interactions (Monitor Closely)

  • Combination with topical corticosteroids: may mask local irritation.
  • Use with systemic hepatotoxic drugs: monitor liver function.
  • Application with other skin products (e.g., moisturizers) may affect absorption.

Frequently Asked Questions

Lamisil is used to treat fungal infections of the skin, groin and nails caused by dermatophytes. The primary indications include athlete’s foot (tinea pedis), ringworm of the body (tinea corporis), jock itch (tinea cruris) and fungal nail infection (tinea unguium or onychomycosis).

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of the fungal cell membrane. The resulting buildup of squalene and loss of ergosterol disrupts membrane integrity, leading to fungal cell death and resolution of the infection.

The dosage and frequency of Lamisil topical are determined by the prescribing healthcare professional based on the infection type, severity and patient characteristics. Patients should follow the prescriber’s instructions and the product label for the correct amount and duration of treatment.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To order Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which targets squalene epoxidase, whereas azoles inhibit lanosterol 14α‑demethylase. Terbinafine often achieves faster fungicidal activity and may be effective against strains resistant to azoles, but the choice of therapy depends on the specific fungus, infection site and patient factors.

Lamisil should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from excessive moisture, direct sunlight and heat sources to maintain its stability and potency.

Apply a thin layer of the cream or gel to the clean, dry skin of the affected area, usually once or twice daily as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands after application unless the hands are being treated.

Serious risks, though rare, include severe allergic reactions such as swelling, hives, difficulty breathing, and life‑threatening conditions like Stevens‑Johnson syndrome. Systemic absorption may also cause liver enzyme elevations, so any signs of jaundice or unusual fatigue should be reported to a healthcare professional promptly.

Individuals with known hypersensitivity to terbinafine, other allylamine antifungals, or any component of the formulation should not use Lamisil. It should also be avoided on extensive broken skin or in patients who are concurrently taking oral terbinafine unless specifically advised by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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