Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical cream for cutaneous use. It treats fungal skin infections such as athlete’s foot, ringworm, jock itch and nail fungus in adults and children.

GNH India supplies Lamisil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is an allylamine antifungal used to treat dermatophyte infections of the skin and nails.

  • Athlete’s foot (tinea pedis): reduces fungal growth and alleviates itching and scaling.
  • Ringworm (tinea corporis): clears skin lesions caused by dermatophytes.
  • Jock itch (tinea cruris): eliminates infection and relieves discomfort.
  • Nail fungus (onychomycosis): improves nail appearance and eradicates fungal colonisation.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol, a vital component of fungal cell membranes. Accumulation of squalene is toxic to the fungus, and depletion of ergosterol disrupts membrane integrity, leading to fungal cell death while having limited effect on human cells.

Side Effects

Terbinafine cream may cause local and systemic reactions.

Common Side Effects

  • Application site irritation: redness, burning or itching at the site of use.
  • Dryness: mild skin dryness where applied.
  • Pruritus: transient itching.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Contact dermatitis: intense skin inflammation.
  • Systemic absorption leading to liver enzyme elevation (rare with extensive use).

Precautions & Warnings

Before using Lamisil cream, consider the following precautions.

  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: avoid application on broken skin and discuss with a physician.
  • Age: safety not established in children under 2 years.
  • Concurrent liver disease: monitor liver function if extensive application is required.
  • Avoid use on extensive broken skin or mucous membranes.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine may interact with other medicines; review the following.

Major Interactions (Avoid)

  • CYP2D6 inhibitors: may increase systemic terbinafine levels when absorbed.
  • Rifampin: may reduce terbinafine efficacy by inducing metabolism.

Moderate Interactions (Monitor Closely)

  • Oral antifungals (itraconazole, fluconazole): concurrent use may increase risk of hepatotoxicity.
  • Alcohol: may exacerbate liver effects.
  • Topical corticosteroids: may alter absorption and efficacy.

Frequently Asked Questions

Lamisil, containing terbinafine hydrochloride, is used to treat fungal skin infections such as athlete’s foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris) and fungal nail infections (onychomycosis). It works by eliminating the dermatophyte fungi that cause these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to toxic buildup of squalene and loss of membrane integrity, causing fungal cell death while sparing human cells.

The specific dosage and frequency of Lamisil cream are determined by the prescribing healthcare professional based on the infection type, severity, patient age and skin condition. Patients should follow the prescriber’s instructions and the product label.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To order Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which typically offers rapid fungicidal activity and a shorter treatment course compared with azole antifungals. It is especially effective against dermatophytes, whereas some alternatives may be less potent for nail infections.

Lamisil cream should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Apply a thin layer of Lamisil cream to the affected area once or twice daily, as directed by the prescriber. Gently rub the cream into clean, dry skin and wash hands after application, unless the hands are being treated.

Serious risks, though rare, include severe allergic reactions such as rash, swelling, or breathing difficulties, and systemic effects like liver enzyme elevation if significant absorption occurs. Patients should seek immediate medical attention if they experience any of these symptoms.

Lamisil should not be used on individuals with known hypersensitivity to terbinafine or any component of the formulation, on extensive broken skin, or on patients with severe liver disease without close monitoring. Children under two years of age should not use the product unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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