Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for topical use. It treats superficial fungal infections of the skin such as athlete's foot, ringworm and jock itch in adults and children. GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil (terbinafine) is indicated for the treatment of superficial dermatophyte infections of the skin.

  • Tinea pedis: alleviates itching and clears fungal infection of the feet.
  • Tinea corporis: resolves ring‑shaped lesions on the body.
  • Tinea cruris: treats fungal infection of the groin area.
  • Other superficial dermatophyte infections: eliminates fungal growth on skin surfaces.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This disruption impairs ergosterol synthesis, a vital component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death without affecting human cells.

Side Effects

Lamisil may cause local skin reactions and, rarely, systemic effects.

Common Side Effects

  • Itching at the application site.
  • Redness or erythema.
  • Burning sensation.
  • Dryness or scaling of the skin.
  • Mild irritation or stinging.
  • Contact dermatitis.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Extensive rash or Stevens‑Johnson syndrome.
  • Bullous pemphigoid.
  • Significant liver enzyme elevation.
  • Systemic hypersensitivity.
  • Unexplained fever or malaise.

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before application.
  • Breastfeeding: discuss potential risks with a physician.
  • Age: use with caution in children; follow pediatric guidance.
  • Skin condition: avoid applying to broken or inflamed skin.
  • Allergy: discontinue use if severe irritation or allergic reaction occurs.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine topical may interact with systemic agents; monitor accordingly.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine therapy: risk of cumulative exposure.
  • Systemic azole antifungals (e.g., itraconazole, ketoconazole): may increase hepatic load.

Moderate Interactions (Monitor Closely)

  • Warfarin: monitor coagulation parameters.
  • Oral contraceptives: possible reduced efficacy.
  • Other topical agents causing irritation: assess skin tolerance.
  • CYP2D6 inhibitors (if systemic absorption is significant): observe for adverse effects.

Frequently Asked Questions

Lamisil is used to treat superficial fungal infections of the skin, including athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris) and other dermatophyte infections that affect the outer layers of the skin.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This leads to a buildup of squalene, disrupting membrane integrity and causing fungal cell death.

The dosage and duration of Lamisil treatment are determined by the prescribing healthcare professional based on the specific infection, its severity, patient age and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety of topical terbinafine during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To order Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which acts by inhibiting squalene epoxidase, whereas azole antifungals (e.g., clotrimazole) inhibit lanosterol 14α‑demethylase. Terbinafine often requires a shorter treatment course and has a favorable safety profile for topical use.

Lamisil should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from excessive moisture, heat and direct sunlight to maintain its stability and effectiveness.

Lamisil is applied topically to the affected skin area, usually once or twice daily as directed by a healthcare professional. The skin should be clean and dry before application, and the medication should be gently rubbed in until fully absorbed.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, extensive skin rash or Stevens‑Johnson syndrome, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms like widespread rash, fever, jaundice or difficulty breathing.

Lamisil should not be used by individuals with a known hypersensitivity to terbinafine or any component of the formulation. It is also contraindicated on severely damaged or inflamed skin and should be used with caution in patients with pre‑existing liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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