Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is a allylamine antifungal presented as a topical formulation for skin use. It treats fungal infections of the skin, hair, and nails in adults and children as directed by a healthcare professional.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil (terbinafine) is used to treat fungal skin infections caused by dermatophytes.

  • Tinea pedis (athlete's foot): reduces itching and clears infection on the feet.
  • Tinea corporis (ringworm): eliminates the expanding red ring lesions on the body.
  • Tinea cruris (jock itch): relieves irritation and eradicates the fungus in the groin area.
  • Tinea unguium (onychomycosis): improves nail appearance by inhibiting fungal growth within the nail plate.

How It Works

  • Terbinafine Hydrochloride inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. By blocking this pathway, the drug causes accumulation of squalene, which is toxic to fungal cells, and depletes ergosterol, disrupting cell membrane integrity and leading to fungal cell death.

Side Effects

Lamisil is generally well tolerated, but some users may experience local reactions.

Common Side Effects

  • Itching at the application site
  • Redness or mild rash
  • Burning or stinging sensation
  • Dryness or peeling of the skin
  • Mild irritation or swelling
  • Scaling or flaking of the treated area

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema)
  • Extensive skin rash or blistering (Stevens‑Johnson syndrome)
  • Swelling of face, lips, or tongue
  • Difficulty breathing or wheezing
  • Hepatotoxicity indicated by abnormal liver enzymes
  • Unusual bruising or bleeding

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Pregnancy: consult a healthcare provider before application.
  • Breastfeeding: discuss potential risks with a doctor.
  • Apply only to intact, non‑broken skin.
  • Avoid extensive use on large body areas without medical advice.
  • Do not apply to mucous membranes, eyes, or genital mucosa.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine may interact with other medications; monitor for combined effects.

Major Interactions (Avoid)

  • Systemic azoles (e.g., itraconazole, fluconazole): may increase terbinafine plasma levels.
  • Strong CYP2D6 inhibitors (e.g., quinidine): can raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask local irritation.
  • Alcohol‑based skin products: could alter absorption.
  • Other dermatologic agents (e.g., salicylic acid, urea): may increase skin irritation.

Frequently Asked Questions

Lamisil is indicated for the topical treatment of common fungal skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), and fungal nail infections (tinea unguium or onychomycosis). It works by targeting the fungus that causes these conditions, helping to relieve symptoms and clear the infection.

Terbinafine Hydrochloride blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. Inhibiting this step leads to toxic buildup of squalene and loss of membrane integrity, ultimately killing the fungal cells and stopping the infection.

The specific dosage and frequency of Lamisil are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and treatment area. Patients should follow the prescriber’s instructions and the product label for proper application.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To place an order, submit an enquiry on the Lamisil product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lamisil belongs to the allylamine class, which differs from azole antifungals that inhibit a later step in ergosterol synthesis. Allylamines like terbinafine often achieve faster fungal clearance and may be preferred for certain dermatophyte infections, though choice depends on infection type, patient factors, and physician judgment.

Lamisil should be stored at room temperature, typically below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Lamisil is applied topically to the affected skin area. Clean and dry the area before use, then spread a thin layer of the cream or gel as directed by the prescriber, usually once or twice daily. Wash hands after application unless the hands are the treatment site.

While rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, extensive skin rashes like Stevens‑Johnson syndrome, and liver toxicity indicated by abnormal liver function tests. Patients should seek immediate medical attention if they notice signs of a serious reaction.

Lamisil should not be used on broken or inflamed skin, on mucous membranes, or by individuals with a known hypersensitivity to terbinafine or any component of the formulation. Patients with severe liver disease should also avoid use unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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