Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for skin application. It treats dermatophyte infections such as athlete’s foot, ringworm and jock itch by targeting the fungal cell membrane.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution. Our supply chain ensures timely delivery and product integrity across European and global markets.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil (terbinafine) is used to treat superficial dermatophyte infections of the skin.

  • Tinea pedis: reduces fungal growth and relieves itching and scaling on the feet.
  • Tinea corporis: clears ring‑shaped lesions and diminishes redness.
  • Tinea cruris: eliminates fungal presence in the groin area and eases discomfort.
  • Tinea versicolor: restores normal skin pigmentation by eradicating yeast overgrowth.
  • Superficial fungal infections: provides broad‑spectrum activity against dermatophytes on the skin.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the biosynthesis of ergosterol, an essential component of fungal cell membranes. By blocking ergosterol production, the drug causes accumulation of toxic squalene and disrupts membrane integrity, leading to fungal cell death. The topical formulation delivers the active compound directly to the infected skin surface, achieving high local concentrations while minimizing systemic exposure.

Side Effects

Topical terbinafine may cause local skin reactions, ranging from mild irritation to rare severe hypersensitivity.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Mild scaling or flaking.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Contact dermatitis with blistering.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis (very rare).

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Avoid application on broken skin: do not use on open wounds or irritated areas.
  • Do not apply to mucous membranes: keep the product away from eyes, mouth and genital mucosa.
  • Check for hypersensitivity: discontinue if rash or swelling develops.
  • Limit duration of use: follow the prescriber's recommended treatment period.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with other topical agents; review the following.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungal agents containing azoles: may increase local irritation.
  • Application together with strong keratolytic agents (e.g., salicylic acid): may enhance systemic absorption.

Moderate Interactions (Monitor Closely)

  • Use with topical corticosteroids: may increase terbinafine penetration and risk of side effects.
  • Combination with other skin irritants (e.g., benzoyl peroxide): monitor for heightened irritation.
  • Co‑application with occlusive dressings: may raise local drug concentration; observe for adverse reactions.

Frequently Asked Questions

Lamisil is indicated for the topical treatment of superficial dermatophyte infections such as tinea pedis (athlete’s foot), tinea corporis (ringworm), tinea cruris (jock itch), tinea versicolor, and other related skin fungal infections. It works by eliminating the causative fungi on the skin surface.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. Inhibiting this pathway leads to toxic squalene buildup and loss of membrane integrity, causing fungal cell death at the site of application.

The specific dose and duration of Lamisil are determined by the prescribing healthcare professional based on the infection type, severity, and patient factors. The prescriber will provide detailed instructions on how much product to apply and for how many days.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To request Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Lamisil belongs to the allylamine class, which acts by inhibiting squalene epoxidase, whereas azole antifungals block lanosterol 14α‑demethylase. Allylamines often achieve faster fungicidal activity and are effective against a broad range of dermatophytes, making Lamisil a preferred option for many superficial infections.

Lamisil should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and efficacy throughout its shelf life.

Apply a thin layer of the cream or solution to the affected area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands before and after application to avoid accidental contact with eyes or mucous membranes.

While uncommon, serious adverse reactions can include severe allergic responses such as angioedema, anaphylaxis, or Stevens‑Johnson syndrome. If any signs of a severe skin reaction, swelling, or difficulty breathing occur, discontinue use immediately and seek emergency medical attention.

Individuals with known hypersensitivity to terbinafine or any component of the formulation should not use Lamisil. It should also be avoided on broken skin, mucous membranes, or in patients where a prescriber determines that the risk outweighs the benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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