Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is a allylamine antifungal presented as a topical formulation for skin application. It treats fungal infections of the skin and nails, such as athlete's foot, ringworm, jock itch, and onychomycosis, in adult and pediatric patients as directed by a healthcare professional.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil (terbinafine) acts on dermatophyte fungi that cause superficial skin and nail infections.

  • Tinea pedis: alleviates itching, scaling and redness of athlete's foot.
  • Tinea corporis: clears ringworm lesions on the body.
  • Tinea cruris: resolves jock itch symptoms in the groin area.
  • Onychomycosis: improves fungal nail infection appearance and reduces fungal load.

How It Works

  • Terbinafine hydrochloride inhibits fungal squalene epoxidase, a key enzyme in the ergosterol biosynthesis pathway. This blockade prevents the formation of ergosterol, an essential component of fungal cell membranes, leading to toxic accumulation of squalene and ultimately causing fungal cell death.

Side Effects

Topical terbinafine is generally well tolerated, but local and systemic reactions can occur.

Common Side Effects

  • Itching: mild to moderate sensation at the application site.
  • Burning: transient heat sensation after application.
  • Redness: localized erythema of treated skin.
  • Dryness or scaling: mild desquamation around the area.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or anaphylaxis.
  • Stevens‑Johnson syndrome: rare severe skin blistering.
  • Hepatotoxicity: abnormal liver enzymes with extensive systemic absorption.
  • Contact dermatitis: intense irritation or rash.
  • Systemic toxicity: rare but may include nausea or headache.

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Broken skin: avoid application on open wounds or extensive abrasions.
  • Liver disease: use with caution and monitor liver function if systemic absorption is possible.
  • Allergy: discontinue if hypersensitivity signs appear.
  • Store at room temperature: keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Terbinafine may interact with other medications, particularly when systemic absorption occurs.

Major Interactions (Avoid)

  • Oral terbinafine: concurrent use can increase systemic exposure.
  • CYP2D6 inhibitors (e.g., fluoxetine): may raise terbinafine levels.
  • Other topical antifungals: avoid simultaneous application to reduce irritation.

Moderate Interactions (Monitor Closely)

  • Alcohol: may exacerbate liver enzyme elevations.
  • Hepatotoxic drugs (e.g., isoniazid): monitor liver function.
  • Warfarin: observe INR if extensive absorption is suspected.

Frequently Asked Questions

Lamisil contains terbinafine hydrochloride and is indicated for superficial fungal infections such as athlete's foot (tinea pedis), ringworm of the body (tinea corporis), jock itch (tinea cruris), and fungal nail infection (onychomycosis). It works on the skin or nail surface to eliminate the causative dermatophytes.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a vital component of fungal cell membranes. Inhibition leads to toxic buildup of squalene and loss of membrane integrity, causing fungal cell death.

The prescribed amount and frequency are determined by the treating clinician based on the infection type, location, and product strength. Patients should follow the healthcare professional’s instructions and not self‑adjust the dose.

Safety data for topical terbinafine in pregnancy and lactation are limited. Use only if the prescriber believes the benefit outweighs any potential risk, and discuss any concerns with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals such as clotrimazole, terbinafine is fungicidal and often requires a shorter treatment course. Its specific inhibition of squalene epoxidase provides rapid fungal clearance, making it a preferred option for many dermatophyte infections.

Store Lamisil at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Apply a thin layer of the cream or solution to the affected skin area once or twice daily, as directed by a healthcare professional. Gently rub it in, wash hands after application, and avoid contact with eyes or mucous membranes.

Rare but serious adverse events include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, and systemic hepatotoxicity. Patients should seek immediate medical attention if they experience swelling, rash, blistering, or signs of liver dysfunction.

Individuals with known hypersensitivity to terbinafine or other allylamine antifungals should avoid Lamisil. It is also contraindicated on extensive broken skin or in patients with severe liver disease unless a physician determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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