Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for skin application. It is used to treat fungal infections of the skin, hair and nails in both adult and pediatric patients when prescribed by a healthcare professional.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Karo Pharma Ab

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Indications & Clinical Uses

Terbinafine is an allylamine antifungal used to treat superficial fungal infections of the skin and nails.

  • Tinea pedis: alleviates itching and clears fungal infection of the feet.
  • Tinea corporis: reduces lesions and eliminates the causative dermatophytes on the body.
  • Tinea cruris: improves redness and scaling in the groin area.
  • Tinea unguium (onychomycosis): promotes clearance of fungal infection in the nails.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in the ergosterol biosynthesis pathway. By blocking this enzyme, the drug prevents formation of ergosterol, an essential component of fungal cell membranes, leading to accumulation of toxic squalene and disruption of membrane integrity, which ultimately kills the fungal cell. The selective inhibition spares human cells because the target pathway is absent in mammalian tissues, allowing topical application with minimal systemic exposure.

Side Effects

Topical terbinafine may cause local skin reactions and, rarely, systemic adverse events.

Common Side Effects

  • Burning sensation: transient warmth at the application site.
  • Itching: mild pruritus around treated area.
  • Redness: localized erythema.
  • Dryness or peeling: mild skin desquamation.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Contact dermatitis: intense rash with blistering.
  • Systemic toxicity: rare liver enzyme elevation if absorbed in large amounts.

Precautions & Warnings

When using Lamisil topical, observe the following precautions to minimize adverse reactions and ensure effectiveness.

  • Apply only to intact skin: avoid open wounds or broken skin.
  • Limit use to prescribed areas: do not spread to unaffected regions.
  • Avoid concurrent use of other topical antifungals unless directed.
  • Discontinue if signs of allergic reaction appear: seek medical advice.
  • Keep out of reach of children: store safely.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine topical can interact with certain substances; awareness of these interactions helps prevent reduced efficacy or increased irritation.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine therapy: may increase systemic exposure and risk of toxicity.
  • Use with strong keratolytic agents (e.g., salicylic acid) on the same site: can enhance skin irritation.

Moderate Interactions (Monitor Closely)

  • Co‑application with other topical antifungals: may increase local irritation.
  • Use with corticosteroid creams: may mask signs of infection.
  • CYP2D6 inhibitors (if systemic absorption occurs): could affect metabolism of systemic terbinafine.
  • Alcohol consumption: may exacerbate skin dryness.

Frequently Asked Questions

Lamisil is the brand name for a topical formulation containing terbinafine hydrochloride. It is employed to treat superficial fungal infections of the skin and nails, including athlete’s foot (tinea pedis), body ringworm (tinea corporis), jock itch (tinea cruris) and nail fungus (tinea unguium or onychomycosis). Treatment is prescribed by a qualified health professional.

Terbinafine works by inhibiting the fungal enzyme squalene epoxidase, a crucial step in the synthesis of ergosterol, an essential component of fungal cell membranes. Blocking this enzyme leads to accumulation of toxic squalene and loss of membrane integrity, which ultimately kills the fungal cell while sparing human cells.

The dosing regimen for Lamisil topical is set by the prescribing clinician based on the specific indication, severity of infection, patient age and the formulation used. Typically a thin layer is applied once daily to the affected area for the duration recommended by the prescriber. Patients should not alter the dose without medical advice.

Safety data for topical terbinafine during pregnancy and lactation are limited. The product should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified health professional. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their doctor.

To place an order, submit an enquiry on the Lamisil product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which acts on the squalene epoxidase pathway, whereas many alternatives such as clotrimazole or miconazole are azole antifungals that inhibit lanosterol 14α‑demethylase. Allylamines often achieve faster clinical cure rates for dermatophyte infections and may require shorter treatment courses, but individual response and tolerability vary.

Lamisil topical should be stored at room temperature, ideally below 25 °C. Keep the product in its original container, tightly closed, and protect it from moisture, direct sunlight and extreme heat. Do not freeze the cream, and keep it out of reach of children.

Apply a thin, even layer of Lamisil to the clean, dry skin of the affected area, usually once daily, unless otherwise directed by a healthcare professional. Gently rub the cream in until it disappears, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

Although rare, serious adverse reactions can include severe allergic responses such as swelling, hives, or difficulty breathing, and contact dermatitis with blistering. Systemic toxicity, such as liver enzyme elevation, is extremely uncommon with topical use but should be reported if symptoms like jaundice or unexplained fatigue occur.

Lamisil topical should not be used by individuals with a known hypersensitivity to terbinafine, other allylamine antifungals, or any component of the formulation. It should also be avoided on broken or inflamed skin unless specifically instructed by a physician. Children under the age recommended by the prescriber should not use the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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