Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for topical use. It treats common fungal skin infections such as tinea corporis, tinea cruris, tinea pedis and tinea barbae in both adults and children.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil is an allylamine antifungal indicated for superficial dermatophyte infections. It works on the skin to eradicate the causative fungi.

  • Tinea corporis: clears ring‑shaped body rash caused by dermatophytes.
  • Tinea cruris: treats groin area fungal infection, reducing redness and itching.
  • Tinea pedis: resolves athlete’s foot symptoms, eliminating scaling and odor.
  • Tinea barbae: eliminates beard‑area fungal infection, promoting normal skin appearance.

How It Works

  • Terbinafine inhibits fungal squalene epoxidase, an enzyme essential for ergosterol synthesis. This blockade leads to accumulation of squalene and depletion of ergosterol, disrupting the fungal cell membrane and causing cell death, thereby clearing the infection.

Side Effects

Topical terbinafine may cause local reactions, most of which are mild and reversible.

Common Side Effects

  • Itching: mild to moderate sensation at the application site.
  • Burning: transient heat sensation during or after application.
  • Redness: localized erythema around the treated area.
  • Scaling: flaking of skin as the infection resolves.
  • Dryness: temporary loss of moisture at the site.
  • Irritation: mild discomfort or stinging.

Serious or Rare Side Effects

  • Contact dermatitis: severe allergic skin reaction requiring medical attention.
  • Angioedema: swelling of face, lips or tongue.
  • Stevens‑Johnson syndrome: rare severe skin disorder.
  • Systemic absorption leading to liver enzyme elevation (very rare with topical use).

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Avoid use on broken skin: do not apply to open wounds or ulcerated areas.
  • Do not apply to eyes or mucous membranes: avoid contact with eyes, mouth or genital mucosa.
  • Check for allergy to terbinafine: discontinue if hypersensitivity develops.
  • Limit use to recommended duration: follow the prescriber's or label's treatment period.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine topical may interact with other skin products or systemic medications.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine: increases total terbinafine exposure.
  • Use with other topical irritants (e.g., salicylic acid): may exacerbate skin irritation.

Moderate Interactions (Monitor Closely)

  • Co‑application with corticosteroid creams: may alter absorption and efficacy.
  • Use with other antifungal agents: potential additive irritation.
  • Concomitant warfarin therapy: theoretical risk of altered coagulation if systemic absorption occurs.

Frequently Asked Questions

Lamisil is used to treat superficial fungal skin infections such as tinea corporis (ringworm of the body), tinea cruris (jock itch), tinea pedis (athlete’s foot) and tinea barbae (beard‑area infection). It works by eliminating the dermatophyte fungi that cause these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is needed to produce ergosterol, a key component of the fungal cell membrane. This inhibition causes squalene to build up and ergosterol to deplete, disrupting the membrane and leading to fungal cell death.

The exact amount of Lamisil to apply and the length of treatment are determined by the prescribing healthcare professional based on the infection type, location and severity. Patients should follow the instructions provided on the product label or by their clinician.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider before using Lamisil.

To request Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which generally provides rapid fungicidal activity and a short treatment course compared with many azole or polyene creams. It is often preferred for dermatophyte infections because of its high cure rates and low systemic absorption when used topically.

Lamisil should be stored at room temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the tube tightly closed helps maintain product stability.

The cream or solution is applied to clean, dry skin in a thin layer, usually twice daily, covering the affected area and a small margin of surrounding healthy skin. Hands should be washed after application, and the treated area should not be covered with airtight dressings unless directed by a clinician.

While rare, serious adverse reactions can include severe allergic responses such as contact dermatitis, angioedema, or Stevens‑Johnson syndrome. If any signs of a serious skin reaction or systemic symptoms appear, the product should be discontinued and medical attention sought immediately.

Individuals with known hypersensitivity to terbinafine or any component of the formulation should avoid using Lamisil. It should also not be applied to broken skin, mucous membranes, or the eyes, and patients with severe liver disease should consult a physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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