Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is a allylamine antifungal presented as a / for topical use. It treats fungal skin infections such as athlete's foot, ringworm, jock itch and tinea versicolor in adults and children.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil is an allylamine antifungal used to treat superficial fungal infections of the skin.

  • Tinea pedis: relieves itching and clears infection of the feet.
  • Tinea corporis: eliminates ring‑shaped lesions on the body.
  • Tinea cruris: treats jock itch in the groin area.
  • Tinea versicolor: reduces discoloured patches caused by yeast.
  • Dermatophytosis: eradicates a broad range of skin‑affecting dermatophytes.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, blocking the conversion of squalene to ergosterol. This disruption impairs the synthesis of ergosterol, an essential component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death.

Side Effects

Lamisil may cause local skin reactions and, rarely, systemic adverse events.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or scaling of the skin.
  • Stinging or tingling feeling.
  • Mild irritation.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Systemic hepatic toxicity (rare with extensive use).
  • Urticaria or hives.
  • Photosensitivity reactions.
  • Anaphylactic shock (extremely rare).

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Assess hypersensitivity: discontinue if allergic reaction occurs.
  • Avoid use on broken or inflamed skin: may increase systemic absorption.
  • Do not apply to mucous membranes: product is for external use only.
  • Limit duration: follow prescribed treatment length to reduce irritation risk.
  • Seek medical advice for extensive or atypical infections.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lamisil may interact with other medications or topical agents.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine (oral): increased systemic exposure.
  • Potent CYP450 inhibitors (e.g., ketoconazole): may raise terbinafine levels.
  • Use with other terbinafine‑containing products: risk of overdose.

Moderate Interactions (Monitor Closely)

  • Co‑application with topical corticosteroids: may mask irritation.
  • Use with other skin irritants (e.g., retinoids): may enhance local discomfort.
  • Combination with phototoxic agents: may increase photosensitivity.

Frequently Asked Questions

Lamisil is indicated for the topical treatment of superficial fungal infections such as athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), and tinea versicolor. It works by eliminating the fungi that cause these skin conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to accumulation of toxic squalene and ultimately kills the fungal cells.

The specific dosage and frequency of Lamisil are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and treatment guidelines. Patients should follow the prescriber's instructions precisely.

Safety data for topical terbinafine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Lamisil (terbinafine) belongs to the allylamine class, which often provides rapid fungicidal activity and shorter treatment courses compared with azole antifungals. Its topical formulation is convenient for localized skin infections, while systemic options may be preferred for extensive disease.

Lamisil should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and effectiveness.

Apply a thin layer of the cream to the affected skin area once or twice daily, as directed by the prescriber. Gently rub in until fully absorbed, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

Serious but rare risks include severe allergic reactions such as Stevens‑Johnson syndrome, systemic hepatic toxicity, and anaphylaxis. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, fever, jaundice, or difficulty breathing.

Lamisil should not be used by individuals with known hypersensitivity to terbinafine or any component of the formulation. It is also contraindicated on broken, inflamed skin or mucous membranes, and should be avoided in patients with severe liver disease without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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