Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is an allylamine antifungal presented as a topical formulation for skin use. It treats fungal infections of the skin and nails in adults and children as directed by a healthcare professional.

GNH India supplies Lamisil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Lamisil is an allylamine antifungal indicated for superficial fungal infections of the skin and nails.

  • Tinea pedis: reduces fungal growth and relieves itching, scaling and redness on the feet.
  • Tinea corporis: clears ring‑shaped lesions by inhibiting the causative dermatophytes.
  • Tinea cruris: alleviates itching and erythema in the groin area.
  • Onychomycosis (topical treatment): improves nail appearance by limiting fungal colonisation on the nail surface.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, which blocks the conversion of squalene to ergosterol. This disruption impairs ergosterol synthesis, a vital component of fungal cell membranes, leading to accumulation of toxic squalene and ultimately causing fungal cell death without affecting human cells.

Side Effects

Common Side Effects

  • Itching at the application site
  • Burning sensation
  • Redness or erythema
  • Dryness or peeling of skin
  • Stinging feeling
  • Mild rash

Serious or Rare Side Effects

  • Severe contact dermatitis
  • Allergic reactions such as swelling or hives
  • Stevens‑Johnson syndrome (very rare)
  • Photosensitivity reactions
  • Significant liver enzyme elevation (systemic absorption)
  • Persistent ulceration or infection at the site of application

Precautions & Warnings

Before using Lamisil, consider the following precautions:

  • Avoid use on broken or inflamed skin: apply only to intact epidermis.
  • Do not apply to mucous membranes: keep away from eyes, mouth and genital mucosa.
  • Limit exposure to sunlight: use sunscreen if treated area will be exposed.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Consult a physician if infection persists beyond the recommended treatment period.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Terbinafine topical may interact with other agents applied to the skin.

Major Interactions (Avoid)

  • Concurrent oral terbinafine: increased risk of systemic toxicity.
  • Topical corticosteroids: may reduce antifungal efficacy.
  • Other topical antifungals: can cause excessive irritation.

Moderate Interactions (Monitor Closely)

  • Alcohol‑based hand sanitizers: may increase skin dryness.
  • Skin care products containing acids (e.g., glycolic acid): monitor for irritation.
  • Phototoxic agents (e.g., psoralen): watch for enhanced photosensitivity.

Frequently Asked Questions

Lamisil is indicated for the topical treatment of superficial fungal infections such as athlete's foot (tinea pedis), ringworm of the body (tinea corporis), jock itch (tinea cruris), and mild cases of nail fungus (topical onychomycosis). It works by targeting the fungi that cause these skin and nail conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. The resulting buildup of squalene and loss of ergosterol compromise the fungal cell structure, leading to cell death while sparing human cells.

The specific dose and frequency of Lamisil are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and treatment guidelines. Patients should follow the prescriber’s instructions and the product label for optimal results.

Safety data for topical terbinafine during pregnancy or lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil.

To place an order, submit an enquiry on the Lamisil product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamisil belongs to the allylamine class, which acts on a different fungal pathway than azole antifungals (e.g., clotrimazole). Allylamines often achieve faster fungal clearance and are effective against dermatophytes resistant to some azoles, making Lamisil a valuable alternative for certain skin infections.

Store Lamisil at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and excessive heat. Ensure the container is tightly closed when not in use to maintain stability.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands before and after application to avoid accidental contact with eyes or mucous membranes.

While uncommon, serious adverse reactions can include severe contact dermatitis, allergic swelling or hives, Stevens‑Johnson syndrome, and systemic effects such as liver enzyme elevation if significant absorption occurs. Patients should stop use and seek medical attention if they notice any severe or unexpected symptoms.

Lamisil should not be used on broken, inflamed or infected skin, on mucous membranes, or by individuals with a known hypersensitivity to terbinafine or any component of the formulation. Patients with severe liver disease should also avoid use unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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