Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is a allylamine antifungal presented as a topical formulation for skin use. It is employed to treat superficial fungal infections of the skin and is indicated for use in adults and children when prescribed by a healthcare professional.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novartis Farmacéutica S.A.

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Indications & Clinical Uses

Lamisil is an allylamine antifungal used to treat infections caused by dermatophytes affecting the skin.

  • Tinea pedis: alleviates itching and clears fungal infection of the feet.
  • Tinea corporis: resolves ring‑shaped lesions on the body.
  • Tinea cruris: treats fungal infection of the groin area.
  • Superficial dermatophytosis: eliminates fungal growth on the skin surface.

How It Works

  • Terbinafine inhibits fungal squalene epoxidase, an enzyme essential for ergosterol synthesis. This inhibition leads to accumulation of squalene and depletion of ergosterol, disrupting the fungal cell membrane structure and causing cell death, thereby clearing the infection.

Side Effects

Terbinafine may cause a range of skin‑related reactions.

Common Side Effects

  • Itching: mild to moderate discomfort at the application site.
  • Redness: localized erythema.
  • Burning sensation: transient heat feeling.
  • Scaling: flaking of the treated skin.
  • Dryness: reduced skin moisture.
  • Irritation: mild stinging or discomfort.

Serious or Rare Side Effects

  • Allergic reaction: hives, swelling, or rash.
  • Severe skin rash: extensive redness or blistering.
  • Swelling of face, lips, or tongue.
  • Difficulty breathing or wheezing.
  • Liver toxicity: jaundice or abnormal liver tests (rare).

Precautions & Warnings

Before using Lamisil, consider the following safety measures.

  • Assess liver function: ensure normal hepatic status prior to therapy.
  • Avoid broken skin: do not apply on open wounds or irritated areas.
  • Monitor for allergic reactions: discontinue if rash or swelling occurs.
  • Use only as prescribed: follow healthcare professional instructions.
  • Keep away from eyes: avoid contact with ocular surfaces.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Cimetidine: may increase terbinafine plasma levels.
  • Ritonavir: can raise terbinafine concentrations, risking toxicity.
  • Nefazodone: may lead to elevated terbinafine exposure.

Moderate Interactions (Monitor Closely)

  • Warfarin: monitor INR for potential anticoagulant effect changes.
  • Oral contraceptives: efficacy may be reduced; consider alternative contraception.
  • Alcohol: increased risk of liver enzyme elevation.
  • Other antifungals: concurrent use may enhance side‑effect profile.
  • Antidiabetic agents: monitor blood glucose as terbinafine may affect metabolism.

Frequently Asked Questions

Lamisil is indicated for the topical treatment of superficial fungal infections such as tinea pedis (athlete's foot), tinea corporis (ringworm of the body), tinea cruris (jock itch), and other forms of superficial dermatophytosis caused by dermatophyte fungi.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of the fungal cell membrane. This blockage leads to squalene buildup and ergosterol depletion, compromising membrane integrity and causing fungal cell death.

The specific dosage and duration of Lamisil therapy are determined by the prescribing healthcare professional based on the infection type, severity, patient age, and other clinical factors. Patients should follow the prescriber’s instructions precisely.

Safety data for topical terbinafine during pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Lamisil to pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Lamisil belongs to the allylamine class, which differs from azole antifungals that inhibit lanosterol 14α‑demethylase. Allylamines like terbinafine often achieve faster fungal clearance with a lower risk of drug‑enzyme interactions, making them a preferred option for many superficial dermatophyte infections.

Lamisil should be stored at room temperature, below 25 °C, in its original container. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and effectiveness.

Lamisil is applied topically to the affected skin area, typically once or twice daily as directed by a healthcare professional. The skin should be clean and dry before application, and the medication should be spread in a thin layer covering the lesion and a small margin of surrounding skin.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, extensive skin rash, and potential liver toxicity. Patients should seek immediate medical attention if they experience symptoms like swelling, difficulty breathing, jaundice, or persistent severe skin irritation.

Lamisil should be avoided in individuals with known hypersensitivity to terbinafine or any component of the formulation. It is also contraindicated on severely damaged or broken skin, and caution is advised for patients with pre‑existing liver disease or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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