Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine, the active ingredient in Lamisil, is a allylamine antifungal presented as an oral dosage form for oral use. It treats dermatophyte infections of the skin and nails, such as athlete’s foot, ringworm, and fungal nail disease, in adult patients.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Novartis S.R.O.,

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Indications & Clinical Uses

Lamisil is an allylamine antifungal indicated for several dermatophyte infections.

  • Tinea pedis: relief of itching and eradication of the fungal infection on the feet.
  • Tinea corporis: treatment of ring‑shaped skin lesions caused by dermatophytes.
  • Onychomycosis: improvement of nail appearance and clearance of fungal invasion in the toenails or fingernails.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, leading to accumulation of squalene and depletion of ergosterol, an essential component of the fungal cell membrane. The resulting disruption of membrane synthesis compromises cell integrity and halts fungal growth, providing a fungicidal effect against dermatophytes and certain yeasts. Because ergosterol is not present in human cells, the drug exhibits selective toxicity toward the pathogen.

Side Effects

Terbinafine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal pain or dyspepsia.
  • Skin reactions: rash, pruritus or mild erythema.
  • Taste disturbances: loss of taste or a bitter taste sensation.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hematologic effects: neutropenia or eosinophilia.
  • Peripheral neuropathy: tingling or numbness in extremities.

Precautions & Warnings

Before prescribing Lamisil, clinicians should consider several precautionary measures to ensure safe use.

  • Liver function: assess baseline hepatic enzymes and monitor during therapy.
  • Drug interactions: review concomitant medications that affect CYP2D6 metabolism.
  • Renal impairment: adjust dose or monitor in patients with severe kidney disease.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Age considerations: use caution in elderly patients due to higher risk of adverse effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging and protect from moisture.

Avoid Interactions

Terbinafine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Itraconazole: combined use may increase risk of hepatotoxicity.
  • Cimetidine: may raise terbinafine plasma concentrations.
  • Rifampicin: can reduce terbinafine levels, diminishing antifungal effect.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Oral contraceptives: potential reduction in efficacy, advise alternative contraception.
  • Antidepressants metabolized by CYP2D6: monitor for altered plasma levels.

Frequently Asked Questions

Lamisil contains terbinafine and is prescribed to treat dermatophyte infections of the skin and nails, including athlete’s foot (tinea pedis), body ringworm (tinea corporis) and fungal nail disease (onychomycosis). It works by eliminating the fungi that cause these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, causing a buildup of squalene and a shortage of ergosterol, which is vital for fungal cell‑membrane formation. This disruption leads to fungal cell death, providing a fungicidal effect against the targeted organisms.

The dosage of Lamisil is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

Safety data for terbinafine in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and only under medical supervision.

To request Lamisil, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals, terbinafine has a different target (squalene epoxidase) and often achieves faster fungal clearance, especially for nail infections. It is generally taken for a shorter duration than some azoles, but drug‑interaction profiles differ, requiring individual assessment.

Lamisil tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Lamisil is administered orally, usually with a glass of water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing relative to meals.

Serious adverse events include liver injury (hepatitis, elevated liver enzymes), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and rare hematologic abnormalities like neutropenia. Patients should seek immediate medical attention if they notice jaundice, rash, or unexplained bruising.

Lamisil is contraindicated in individuals with known hypersensitivity to terbinafine or any component of the formulation. Caution is also advised for patients with pre‑existing liver disease, severe renal impairment, or those taking medications that strongly interact with terbinafine metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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