Product image of Lamisil (Terbinafine Hydrochloride) supplied by GNH India

Lamisil

Active Ingredient:
Terbinafine Hydrochloride
Origin:
EU

Lamisil (Terbinafine Hydrochloride)

Terbinafine Hydrochloride, the active ingredient in Lamisil, is an allylamine antifungal presented as an oral tablet for oral use. It treats dermatophyte skin infections such as athlete's foot and ringworm, as well as fungal nail infections in adult patients.

GNH India supplies Lamisil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novartis Pharma S.A.S.

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Indications & Clinical Uses

Lamisil is an allylamine antifungal indicated for infections caused by dermatophyte fungi.

  • Tinea pedis (athlete's foot): clears the infection and relieves itching and scaling.
  • Tinea corporis (ringworm): eliminates fungal growth and promotes normal skin healing.
  • Onychomycosis (fungal nail infection): eradicates nail fungus and improves nail appearance.

How It Works

  • Terbinafine Hydrochloride inhibits the fungal enzyme squalene epoxidase, leading to accumulation of squalene and depletion of ergosterol in the cell membrane. This disruption compromises membrane integrity, halting fungal cell growth and causing cell death, while having limited effect on human cells.

Side Effects

Adverse reactions may occur with oral terbinafine therapy.

Common Side Effects

  • Gastrointestinal upset (nausea, abdominal pain)
  • Headache
  • Rash or mild skin irritation
  • Altered taste sensation
  • Elevated liver enzymes (asymptomatic)

Serious or Rare Side Effects

  • Hepatotoxicity (clinical hepatitis, jaundice)
  • Severe cutaneous reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis)
  • Hematologic abnormalities (eosinophilia, neutropenia)
  • Anaphylactic or severe allergic reactions
  • Peripheral neuropathy

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Liver function monitoring: assess baseline hepatic enzymes and repeat if clinically indicated.
  • Hypersensitivity: avoid in patients with known allergy to terbinafine or other allylamines.
  • Concomitant hepatotoxic drugs: use with caution when combined with other agents that affect liver function.
  • Renal impairment: adjust therapy only under medical supervision.
  • Pediatric use: not recommended for children under 18 years without specialist advice.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with several medicines; categorize as follows.

Major Interactions (Avoid)

  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) – may increase terbinafine levels.
  • Potent CYP3A4 inducers (e.g., rifampin, carbamazepine) – may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Cimetidine – may raise terbinafine plasma concentrations.
  • Itraconazole or other azole antifungals – additive hepatotoxic risk.
  • Warfarin – monitor INR for possible increased anticoagulant effect.
  • Oral contraceptives – reduced effectiveness reported; consider alternative contraception.
  • Alcohol – may exacerbate liver enzyme elevations.

Frequently Asked Questions

Lamisil is prescribed for dermatophyte infections of the skin such as tinea pedis (athlete's foot) and tinea corporis (ringworm), as well as for onychomycosis, which is a fungal infection of the toenails or fingernails. It targets the fungi that cause these conditions and helps clear the infection.

Terbinafine Hydrochloride blocks the fungal enzyme squalene epoxidase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. The resulting membrane disruption stops fungal growth and leads to cell death, while human cells are largely unaffected.

The specific dose and duration of Lamisil therapy are determined by the prescribing healthcare professional based on the type and severity of the infection, patient age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Safety data for terbinafine in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by the prescriber in consultation with the patient.

To request Lamisil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals such as itraconazole or fluconazole, terbinafine has a different mechanism (squalene epoxidase inhibition) and often achieves higher cure rates for dermatophyte skin infections and onychomycosis. It is generally taken for a shorter period, but liver monitoring remains important.

Lamisil tablets should be stored at or below 25 °C (77 °F) in their original container, protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Lamisil is taken orally as a tablet, usually with a full glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew.

The most serious adverse events include liver toxicity, which may present as jaundice or elevated liver enzymes, and severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should report any signs of liver dysfunction or rash promptly to their healthcare provider.

Lamisil should be avoided in individuals with a known hypersensitivity to terbinafine or other allylamine antifungals, in patients with severe liver disease, and in children under the age recommended by the prescriber. Caution is also advised for patients taking multiple hepatotoxic drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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