Product image of Lamisil Uno (Terbinafine) supplied by GNH India

Lamisil Uno

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Uno (Terbinafine)

Terbinafine, the active ingredient in Lamisil Uno, is an allylamine antifungal presented as a topical formulation for topical use. It treats superficial dermatophyte infections such as athlete's foot, ringworm and jock itch in adults and children.

GNH India supplies Lamisil Uno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is indicated for the treatment of superficial fungal infections caused by dermatophytes.

  • Tinea pedis (athlete's foot): reduces itching and clears the infection on the feet.
  • Tinea corporis (ringworm): eliminates the rash and prevents spread on the body.
  • Tinea cruris (jock itch): relieves irritation and eradicates the fungus in the groin area.

How It Works

  • Terbinafine inhibits fungal squalene epoxidase, an enzyme essential for ergosterol synthesis. This blockage leads to accumulation of toxic squalene within the fungal cell and depletion of ergosterol, compromising membrane integrity and ultimately causing fungal cell death.

Side Effects

Terbinafine is generally well tolerated when applied to the skin, but some adverse reactions may occur.

Common Side Effects

  • Local itching or burning at the application site.
  • Redness or mild rash.
  • Dryness or peeling of the skin.
  • Stinging sensation.
  • Minor swelling.
  • Slight irritation.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., swelling of face, lips, tongue).
  • Contact dermatitis with blistering.
  • Widespread rash or hives.
  • Significant skin discoloration.
  • Systemic symptoms such as fever or malaise.
  • Unexplained liver enzyme elevation (rare).

Precautions & Warnings

Before using Lamisil Uno, consider the following safety measures.

  • Allergy Check: avoid if you have known hypersensitivity to terbinafine or formulation excipients.
  • Skin Integrity: do not apply to broken, inflamed, or infected skin beyond the fungal infection.
  • Age Consideration: use in children only under medical supervision.
  • Concomitant Medications: inform your clinician of any systemic antifungal or liver‑affecting drugs.
  • Pregnancy & Breastfeeding: discuss risks with a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine may interact with other medicines, especially when systemic absorption occurs.

Major Interactions (Avoid)

  • Oral antifungal agents (e.g., itraconazole, fluconazole) that share metabolic pathways.
  • Drugs highly dependent on CYP2D6 metabolism, as terbinafine can inhibit this enzyme.

Moderate Interactions (Monitor Closely)

  • Hepatotoxic medications (e.g., acetaminophen high doses) requiring liver function monitoring.
  • Warfarin, where altered metabolism may affect coagulation parameters.
  • Topical corticosteroids applied to the same area, which may increase systemic absorption.

Frequently Asked Questions

Lamisil Uno is a topical antifungal medication used to treat superficial skin infections caused by dermatophytes, including athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It works by applying the medication directly to the affected area to eliminate the fungus and relieve symptoms.

Terbinafine belongs to the allylamine class of antifungals. It blocks the fungal enzyme squalene epoxidase, which is required for synthesising ergosterol, a key component of fungal cell membranes. The resulting buildup of squalene and loss of ergosterol disrupts membrane integrity, leading to fungal cell death.

The specific dosing regimen for Lamisil Uno is determined by the prescribing clinician based on the infection type, severity, patient age and skin condition. Typically, a thin layer is applied to the clean, dry affected area once or twice daily for the period recommended by the healthcare professional.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Uno.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.

Compared with azole antifungals, terbinafine has a different mechanism targeting squalene epoxidase, which can result in faster fungal clearance for dermatophyte infections. It is often preferred for its once‑ or twice‑daily dosing and lower potential for drug‑enzyme interactions, though choice of therapy should be individualized by a clinician.

Store Lamisil Uno at room temperature, ideally below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children. Do not freeze or expose the product to extreme temperatures.

Before application, wash and thoroughly dry the affected skin area. Apply a thin layer of the cream or gel to the lesion and a small margin of surrounding healthy skin. Rub gently until the product is absorbed. Follow the frequency and duration prescribed by your healthcare professional.

Although rare, serious adverse reactions can include severe allergic responses such as facial swelling, difficulty breathing, or widespread rash. Systemic absorption may rarely cause liver enzyme abnormalities. Patients should seek immediate medical attention if they experience signs of a serious allergic reaction or unexplained systemic symptoms.

Lamisil Uno should be avoided by individuals with a known hypersensitivity to terbinafine, its excipients, or any allylamine antifungal. It is also contraindicated on severely damaged, inflamed or infected skin not related to a fungal infection, and should be used with caution in patients with pre‑existing liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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