Product image of Lamisil Uno (Terbinafine) supplied by GNH India

Lamisil Uno

Active Ingredient:
Terbinafine
Origin:
EU

Lamisil Uno (Terbinafine)

Terbinafine, the active ingredient in Lamisil Uno, is an allylamine antifungal presented as a topical cream for cutaneous use. It treats common fungal skin infections such as athlete's foot, ringworm and jock itch by targeting the fungal cell membrane.
GNH India supplies Lamisil Uno as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is used to treat superficial fungal infections of the skin and hair.

  • Tinea pedis (athlete's foot): reduces itching, scaling and erythema caused by dermatophyte infection.
  • Tinea corporis (ringworm): clears annular lesions and prevents spread to adjacent skin.
  • Tinea cruris (jock itch): alleviates redness, maceration and discomfort in the groin area.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. By blocking this pathway, the drug causes accumulation of toxic squalene within the fungal cell and depletes ergosterol, compromising membrane integrity and leading to fungal cell death.

Side Effects

Terbinafine may cause local skin reactions and, rarely, systemic hypersensitivity.

Common Side Effects

  • Burning sensation at the application site
  • Itching or pruritus
  • Redness or erythema
  • Dryness or peeling of skin
  • Mild rash
  • Stinging or tingling feeling

Serious or Rare Side Effects

  • Severe allergic reaction (angioedema, anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Extensive skin blistering
  • Systemic hypersensitivity with fever
  • Significant swelling of face or throat

Precautions & Warnings

Before using Lamisil Uno, consider the following precautions.

  • Confirm diagnosis: ensure the condition is a dermatophyte infection before application.
  • Avoid broken skin: do not apply to open wounds or inflamed lesions.
  • Limited body surface: restrict use to affected areas and avoid extensive coverage.
  • Hepatic caution: use with care in patients with known liver disease, monitoring if systemic absorption is suspected.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Terbinafine topical has a low potential for systemic drug interactions, but certain combinations may affect safety or efficacy.

Major Interactions (Avoid)

  • Concurrent use with other topical irritants (e.g., strong corticosteroids) may increase skin irritation.
  • Application over areas treated with chemical peels or laser therapy can exacerbate local reactions.

Moderate Interactions (Monitor Closely)

  • Use with other antifungal agents may alter therapeutic outcomes; monitor for reduced effectiveness.
  • Co‑application with moisturizers containing alcohol may increase dryness; observe skin condition.
  • Systemic terbinafine taken concurrently can increase overall exposure; assess for hepatic side effects.

Frequently Asked Questions

Lamisil Uno is a topical formulation containing terbinafine that is indicated for the treatment of superficial fungal skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis) and jock itch (tinea cruris). It works by eliminating the dermatophyte organisms responsible for these conditions.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Inhibition leads to toxic squalene buildup and loss of membrane integrity, causing fungal cell death and resolution of the infection.

The dosage of Lamisil Uno is determined by the prescribing healthcare professional based on the type and extent of the infection. The prescriber will specify the amount of cream to apply, the frequency of application, and the duration of therapy.

Safety data for topical terbinafine during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Lamisil Uno.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals, terbinafine has a different mechanism—blocking squalene epoxidase rather than inhibiting lanosterol 14α‑demethylase. This often results in faster clinical cure rates for dermatophyte infections and a lower potential for drug‑drug interactions when used topically.

Lamisil Uno should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and effectiveness.

The cream is applied to clean, dry skin on the affected area. A thin layer is spread gently and rubbed in until fully absorbed. The prescriber will advise how often to apply—typically once or twice daily—and for how many days, depending on the infection.

Although rare, serious adverse reactions can include severe allergic responses such as angioedema, anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis. Immediate medical attention is required if signs of a severe skin reaction or systemic allergy develop.

Lamisil Uno should not be used by individuals with a known hypersensitivity to terbinafine or any component of the formulation. It is also contraindicated on broken or severely inflamed skin, and caution is advised in patients with significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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