Product image of Lamisilonce (Terbinafine) supplied by GNH India

Lamisilonce

Active Ingredient:
Terbinafine
Origin:
EU

Lamisilonce (Terbinafine)

Terbinafine, the active ingredient in Lamisilonce, is a allylamine antifungal presented as a topical formulation for topical use. It treats dermatophyte skin infections such as athlete's foot, ringworm, and jock itch in adults and children.

GNH India supplies Lamisilonce as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Karo Healthcare Ab

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Indications & Clinical Uses

Terbinafine is used to treat fungal skin infections caused by dermatophytes.

  • Tinea pedis: relief of itching and eradication of the causative fungus.
  • Tinea corporis: clearance of ring‑shaped lesions and prevention of spread.
  • Tinea cruris: reduction of inflammation and elimination of the infection.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, a key step in ergosterol biosynthesis. By blocking this pathway, the drug causes accumulation of squalene, which is toxic to fungal cells, and depletes ergosterol, compromising cell membrane integrity and leading to fungal cell death.

Side Effects

Common side effects are usually mild and limited to the application site.

Common Side Effects

  • Itching: mild to moderate sensation at the site of application.
  • Burning: transient heat sensation during or after use.
  • Redness: localized erythema.
  • Dryness or scaling: mild skin desquamation.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rapid onset of swelling, difficulty breathing.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin detachment.
  • Severe skin rash: widespread erythematous eruption.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Contact dermatitis: intense local inflammation.

Precautions & Warnings

Before using Lamisilonce, consider the following precautions.

  • Apply to intact skin only: avoid broken or inflamed areas.
  • Avoid use on mucous membranes: do not apply to eyes, nose, or mouth.
  • Limit duration: follow prescriber instructions, typically up to four weeks.
  • Monitor for allergic reactions: discontinue if a severe rash or swelling develops.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Terbinafine may interact with other medications or topical agents.

Major Interactions (Avoid)

  • Concurrent systemic terbinafine: may increase systemic exposure and risk of toxicity.
  • Oral antifungals metabolized by CYP2D6: potential additive hepatic effects.

Moderate Interactions (Monitor Closely)

  • Use with other topical irritants (e.g., corticosteroids): may increase skin irritation.
  • Use with occlusive dressings: may enhance percutaneous absorption.
  • Concurrent photosensitizing agents: may increase risk of sunburn.

Frequently Asked Questions

Lamisilonce is a topical antifungal medication indicated for the treatment of dermatophyte skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris). It works on the skin surface to eliminate the fungi that cause these conditions.

Terbinafine inhibits the fungal enzyme squalene epoxidase, which is essential for ergosterol synthesis. Blocking this step leads to toxic accumulation of squalene and depletion of ergosterol, disrupting the fungal cell membrane and causing fungal cell death.

The specific amount and frequency of Lamisilonce are determined by the prescribing healthcare professional based on the infection type, severity, and patient characteristics. Patients should follow the prescriber’s instructions and not alter the regimen on their own.

Safety data for topical terbinafine during pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against possible risks and discuss any concerns with the patient before prescribing.

To request Lamisilonce, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with azole antifungals, terbinafine has a different target (squalene epoxidase) and often achieves faster clinical cure rates for dermatophyte infections. It is generally well‑tolerated topically, but choice of therapy should consider infection type, patient history and local resistance patterns.

Lamisilonce should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Apply a thin layer of the cream to the affected skin area once or twice daily, as directed by the prescriber. Wash hands before and after application, and avoid covering the treated area with airtight dressings unless instructed.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, extensive skin rashes like Stevens‑Johnson syndrome or toxic epidermal necrolysis, and signs of liver dysfunction. Patients should seek immediate medical attention if they notice swelling, difficulty breathing, widespread rash, or jaundice.

Individuals with known hypersensitivity to terbinafine or any component of the formulation should avoid using Lamisilonce. It is also contraindicated on broken skin, mucous membranes, or in patients who have experienced severe systemic reactions to topical antifungals.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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