Product image of Lamivir (Lamivudine) supplied by GNH India

Lamivir

Active Ingredient:
Lamivudine
Origin:
EU

Lamivir (Lamivudine)

Lamivudine, the active ingredient in Lamivir, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as an oral formulation for oral use. It treats human immunodeficiency virus (HIV) infection and chronic hepatitis B infection in adult patients.

GNH India supplies Lamivir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medicopharm Ag

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Indications & Clinical Uses

  • Lamivudine is used in the management of viral infections that involve reverse transcriptase activity.
  • HIV infection: reduces viral load and helps restore immune function.
  • Chronic hepatitis B infection: suppresses HBV replication and decreases liver inflammation.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA. Once incorporated, it acts as a chain terminator, preventing elongation of the viral DNA strand and thereby inhibiting HIV reverse transcriptase and hepatitis B polymerase activity.

Side Effects

Lamivudine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Fatigue: general tiredness without exertion.
  • Diarrhea: loose stools, usually self‑limiting.

Serious or Rare Side Effects

  • Lactic acidosis: rare metabolic disturbance requiring immediate medical attention.
  • Severe hepatotoxicity: marked liver enzyme elevation or failure.
  • Pancreatitis: inflammation of the pancreas with abdominal pain.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • Before initiating lamivudine therapy, clinicians should consider several safety measures.
  • Monitor liver function: perform baseline and periodic hepatic enzyme tests.
  • Assess renal function: evaluate creatinine clearance for possible dose adjustment.
  • Screen for hepatitis B co‑infection: identify risk of viral reactivation.
  • Counsel on adherence: emphasize the importance of consistent daily dosing.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lamivudine can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened peripheral neuropathy risk.
  • Ribavirin: may exacerbate hemolytic anemia.

Moderate Interactions (Monitor Closely)

  • Efavirenz: possible reduction in lamivudine plasma levels.
  • Nevirapine: monitor liver enzymes for hepatotoxicity.
  • Alcohol: may increase liver toxicity risk.

Frequently Asked Questions

Lamivir contains lamivudine, which is prescribed for managing HIV infection and chronic hepatitis B infection. In both conditions, the drug helps suppress viral replication, improving immune function in HIV and reducing liver inflammation in hepatitis B.

Lamivudine is converted inside cells to its active triphosphate form. This active metabolite mimics natural nucleosides and is incorporated into viral DNA by reverse transcriptase, causing premature chain termination and halting viral replication.

The specific dose of Lamivir is determined by the prescribing healthcare professional based on the patient’s condition, weight, renal function, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for lamivudine in pregnancy and lactation are limited. Healthcare providers weigh potential benefits against risks before prescribing to pregnant or nursing individuals. Patients should discuss any concerns with their clinician.

To request Lamivir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Lamivir (lamivudine) belongs to the nucleoside reverse transcriptase inhibitor class, offering a well‑established safety profile and convenient oral dosing. Compared with some protease inhibitors, it has fewer metabolic side effects, but it is often used in combination with other agents to achieve optimal viral suppression.

Lamivir should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability.

Lamivir is taken orally, usually as a tablet, with or without food. The exact administration schedule is set by the prescriber and should be adhered to for consistent therapeutic effect.

Serious risks include lactic acidosis, severe hepatotoxicity, pancreatitis, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience unexplained fatigue, abdominal pain, jaundice, or skin rash.

Lamivir is contraindicated in patients with known hypersensitivity to lamivudine or any of its excipients. Caution is also advised for individuals with pre‑existing severe liver disease or mitochondrial disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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