Product image of Lamivudin Aurobindo (Lamivudine) supplied by GNH India

Lamivudin Aurobindo

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudin Aurobindo (Lamivudine)

Lamivudine, the active ingredient in Lamivudin Aurobindo, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as an oral tablet for oral use. It treats HIV infection and chronic hepatitis B in adults and children as prescribed.

GNH India supplies Lamivudin Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Puren Pharma Gmbh & Co. Kg

1
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Indications & Clinical Uses

Lamivudin Aurobindo is used in the management of viral infections that target the reverse transcriptase pathway.

  • HIV infection: reduces viral load and helps restore immune function.
  • Chronic hepatitis B: suppresses viral replication and improves liver enzyme levels.
  • HIV/HBV co‑infection: provides simultaneous control of both viruses in patients with dual infection.

How It Works

  • Lamivudine is a nucleoside analogue that competes with natural deoxycytidine triphosphate for incorporation into viral DNA by HIV reverse transcriptase. Once incorporated, it lacks a 3'-hydroxyl group, causing premature chain termination and preventing further elongation of the viral genome, thereby inhibiting viral replication.

Side Effects

Lamivudin Aurobindo may cause a range of adverse reactions. Most are mild and reversible, but serious events can occur.

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Diarrhea
  • Insomnia
  • Abdominal pain

Serious or Rare Side Effects

  • Lactic acidosis
  • Severe hepatotoxicity
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Pancreatitis
  • Severe hypersensitivity reactions
  • Grade 3–4 neutropenia or anemia

Precautions & Warnings

Lamivudin Aurobindo requires careful monitoring and patient counseling to minimise risks.

  • Liver function monitoring: assess baseline enzymes and repeat periodically.
  • Renal function assessment: adjust dose in severe impairment.
  • HBV reactivation watch: monitor hepatitis B surface antigen in patients discontinuing therapy.
  • Adherence counseling: emphasize the importance of consistent dosing to prevent resistance.
  • Hypersensitivity avoidance: discontinue if severe rash or anaphylaxis occurs.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamivudin Aurobindo can interact with several antiretroviral and non‑antiretroviral agents.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened mitochondrial toxicity.
  • Ribavirin: enhanced hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • Efavirenz: possible reduction in lamivudine plasma levels.
  • Nevirapine: potential liver enzyme elevation.
  • Alcohol: may exacerbate hepatic adverse effects.

Frequently Asked Questions

Lamivudin Aurobindo contains lamivudine, an antiretroviral drug indicated for the treatment of HIV infection and chronic hepatitis B. It is prescribed to reduce viral load, improve immune function in HIV, and suppress hepatitis B virus replication in infected patients.

Lamivudine is a nucleoside analogue that mimics natural nucleotides. It is incorporated into viral DNA by reverse transcriptase, lacking a 3'-hydroxyl group, which halts DNA chain elongation and prevents the virus from replicating its genome.

The specific dose of Lamivudin Aurobindo is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and treatment guidelines. Only a qualified healthcare professional should set the dosing regimen.

Safety data for lamivudine in pregnancy are limited, and the medication should only be used if the potential benefit justifies any potential risk to the fetus. Breastfeeding decisions should be made with a healthcare provider, as lamivudine can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lamivudine is a nucleoside reverse transcriptase inhibitor, often used in combination regimens. Compared with other NRTIs, it has a favorable safety profile and low pill burden, but resistance can develop if used as monotherapy. Clinicians typically combine it with drugs from other classes for optimal viral suppression.

Lamivudin Aurobindo tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.

The medication is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water. Patients should follow the dosing schedule precisely to maintain effective drug levels.

Serious adverse events include lactic acidosis, severe hepatotoxicity, Stevens‑Johnson syndrome, and pancreatitis. Patients should be monitored for unexplained fatigue, abdominal pain, jaundice, rash, or signs of pancreatic inflammation, and seek immediate medical attention if these occur.

Lamivudin Aurobindo should be avoided in individuals with known hypersensitivity to lamivudine or any of the tablet excipients. Caution is also advised for patients with severe hepatic or renal impairment, and it is not recommended for use in patients with active, severe mitochondrial disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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