Product image of Lamivudin Mylan (Lamivudine) supplied by GNH India

Lamivudin Mylan

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudin Mylan (Lamivudine)

Lamivudine, the active ingredient in Lamivudin Mylan, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It treats human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection in adult patients.

GNH India supplies Lamivudin Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Germany Gmbh

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Indications & Clinical Uses

Lamivudin Mylan is an antiretroviral nucleoside analogue used to manage viral infections that rely on reverse transcription.

  • HIV infection: reduces plasma HIV‑RNA levels and helps restore immune function.
  • Chronic hepatitis B infection: suppresses HBV DNA replication and lowers liver inflammation.
  • HIV/HBV co‑infection: provides simultaneous control of both viruses in patients with dual infection.

How It Works

  • Lamivudine is phosphorylated inside cells to its active triphosphate form, which competitively inhibits HIV reverse transcriptase and is incorporated into viral DNA. This incorporation terminates the DNA chain, preventing further viral replication. In hepatitis B, the same mechanism blocks the viral polymerase, reducing HBV DNA synthesis.

Side Effects

Lamivudin Mylan may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Fatigue: generalized tiredness.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic disturbance requiring immediate medical attention.
  • Hepatotoxicity: significant liver enzyme elevation or failure.
  • Pancreatitis: inflammation of the pancreas with abdominal pain.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hypersensitivity: rash, fever, or organ involvement.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient-specific risk factors and monitor for adverse events.

  • Liver function monitoring: check transaminases regularly, especially in patients with pre‑existing liver disease.
  • Renal function assessment: adjust dosing if creatinine clearance is reduced.
  • Mitochondrial toxicity vigilance: watch for signs of lactic acidosis or hepatic steatosis.
  • Adherence counseling: emphasize the importance of consistent dosing to prevent resistance.
  • Hypersensitivity awareness: discontinue if severe rash or systemic reaction occurs.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudin Mylan can affect, or be affected by, several concomitant medicines.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis and peripheral neuropathy.
  • Stavudine: heightened mitochondrial toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampin: may reduce lamivudine plasma concentrations.
  • Antacids containing aluminium or magnesium: can lower absorption; separate dosing by at least 2 hours.
  • Warfarin: monitor INR as lamivudine may potentiate anticoagulant effect.

Frequently Asked Questions

Lamivudin Mylan contains lamivudine, which is indicated for the treatment of human immunodeficiency virus (HIV) infection and chronic hepatitis B virus (HBV) infection in adult patients. It may also be used in individuals co‑infected with both HIV and HBV to control viral replication of each pathogen.

Lamivudine is taken up by cells and phosphorylated to its active triphosphate form. This active metabolite competes with natural nucleosides for the reverse transcriptase enzyme of HIV and the polymerase of HBV, becoming incorporated into viral DNA and causing premature chain termination, thereby halting viral replication.

The exact dose of Lamivudin Mylan is determined by the prescribing clinician based on the individual’s clinical condition, viral load, renal function, and other factors. Healthcare professionals follow established treatment guidelines and adjust the regimen as needed.

The safety of lamivudine in pregnancy and lactation has not been definitively established. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To request Lamivudin Mylan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lamivudin Mylan belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class, offering a well‑characterised safety profile and convenient oral dosing. Compared with newer agents, it may have fewer drug‑interaction concerns but can be combined with other antiretrovirals for a potent regimen. Choice of therapy depends on resistance patterns, patient comorbidities, and guideline recommendations.

Lamivudin Mylan should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Lamivudin Mylan is administered orally, typically as a tablet taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional and swallow the tablet whole with water.

Serious risks include lactic acidosis, severe hepatotoxicity, pancreatitis, and hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be educated to seek immediate medical attention if they experience unexplained abdominal pain, rapid breathing, severe fatigue, jaundice, or a rash with systemic symptoms.

Lamivudin Mylan is contraindicated in individuals with known hypersensitivity to lamivudine or any of the tablet’s excipients. Caution is also advised for patients with pre‑existing severe liver disease, mitochondrial disorders, or those receiving contraindicated drugs such as didanosine or stavudine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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