Product image of Lamivudina Aurobindo Italia (Lamivudine) supplied by GNH India

Lamivudina Aurobindo Italia

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudina Aurobindo Italia (Lamivudine)

Lamivudine, the active ingredient in Lamivudina Aurobindo Italia, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as a tablet for oral use. It treats HIV infection and chronic hepatitis B in appropriate patients.

GNH India supplies Lamivudina Aurobindo Italia as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Lamivudine is employed in antiretroviral therapy targeting viral replication in HIV and hepatitis B infections.

  • HIV infection: reduces viral load and helps restore immune function.
  • Chronic hepatitis B infection: suppresses viral replication and diminishes liver inflammation.
  • Prevention of mother-to-child transmission of HIV: lowers the risk of vertical transmission during pregnancy and delivery.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA. Once incorporated by HIV reverse transcriptase, it causes chain termination, halting viral DNA synthesis and thereby inhibiting replication of HIV and hepatitis B virus.

Side Effects

Lamivudine may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: occasional tension-type headaches.
  • Fatigue: feeling of tiredness or low energy.
  • Diarrhea: loose stools, usually transient.
  • Insomnia: difficulty falling or staying asleep.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Lactic acidosis: buildup of lactic acid, a medical emergency.
  • Severe hepatomegaly with steatosis: significant liver enlargement with fat accumulation.
  • Pancreatitis: inflammation of the pancreas, presenting with abdominal pain.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin reactions.
  • Hypersensitivity reactions: rash, fever, and organ involvement.

Precautions & Warnings

Lamivudine requires careful monitoring and patient counseling.

  • Monitor liver function: obtain baseline and periodic liver enzyme tests.
  • Assess renal function: adjust dosing in patients with impaired kidneys.
  • Pregnancy category B: use only if the potential benefit justifies the potential risk.
  • Avoid in patients with known hypersensitivity to lamivudine or any component of the formulation.
  • Counsel on adherence: missed doses can lead to viral resistance.
  • Store at ambient temperature: keep below 25°C, protect from moisture, and retain in the original packaging.

Avoid Interactions

Lamivudine can interact with several other medicines.

Major Interactions (Avoid)

  • Didanosine: concurrent use increases the risk of pancreatitis.
  • Stavudine: combined use may exacerbate peripheral neuropathy.
  • Other NRTIs with mitochondrial toxicity: may increase risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Protease inhibitors (e.g., ritonavir): may raise lamivudine plasma levels.
  • Nephrotoxic agents (e.g., aminoglycosides): require renal function monitoring.
  • Alcohol: concurrent use may worsen liver toxicity.

Frequently Asked Questions

Lamivudina Aurobindo Italia contains lamivudine, which is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection and chronic hepatitis B infection. It is used as part of combination antiretroviral therapy to control viral replication and improve immune function in HIV‑positive patients, and to suppress hepatitis B virus replication in chronic carriers.

Lamivudine is a nucleoside analogue that is converted inside cells to its active triphosphate form. This active metabolite competes with natural nucleosides for incorporation into viral DNA by reverse transcriptase. Once incorporated, it terminates the DNA chain, preventing further viral replication of HIV and hepatitis B virus.

The specific dosing regimen for Lamivudina Aurobindo Italia is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and other individual factors. Healthcare professionals should follow current clinical guidelines and adjust the dose as needed for each patient.

Lamivudine is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy if the potential benefit outweighs any possible risk. Lamivudine is excreted in breast milk, so a risk‑benefit assessment should be performed before breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lamivudina Aurobindo Italia. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often combined with other antiretrovirals for synergistic effect. Compared with older NRTIs such as zidovudine, lamivudine generally has a more favorable safety profile, fewer mitochondrial toxicities, and is active against both HIV and hepatitis B, making it a versatile component of combination regimens.

Lamivudina Aurobindo Italia should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The medication is taken orally, usually as a tablet, with or without food as directed by the prescribing clinician. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed to maintain consistent drug levels.

Serious adverse events, although rare, include lactic acidosis, severe hepatomegaly with steatosis, pancreatitis, and severe skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Lamivudina Aurobindo Italia should be avoided in individuals with known hypersensitivity to lamivudine or any excipients in the formulation. Caution is also advised for patients with severe hepatic impairment, mitochondrial disorders, or those who are pregnant without a clear clinical indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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