Product image of Lamivudina Farmoz (Lamivudine) supplied by GNH India

Lamivudina Farmoz

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudina Farmoz (Lamivudine)

Lamivudine, the active ingredient in Lamivudina Farmoz, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as an oral formulation for oral use. It is used to treat HIV-1 infection and chronic hepatitis B infection in appropriate patients.
GNH India supplies Lamivudina Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Lamivudine is indicated for viral infections that involve reverse transcriptase activity.

  • HIV-1 infection: reduces viral load and helps maintain immune function when used in combination therapy.
  • Chronic hepatitis B infection: suppresses viral replication and improves liver function in infected individuals.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA by HIV reverse transcriptase. Incorporation results in chain termination, preventing elongation of viral DNA and thereby inhibiting viral replication.

Side Effects

Lamivudine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort.
  • Headache: transient cranial pain.
  • Fatigue: general tiredness.
  • Diarrhea: loose stools.
  • Insomnia: difficulty sleeping.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic disturbance requiring immediate medical attention.
  • Hepatomegaly with steatosis: liver enlargement with fat accumulation.
  • Severe rash or hypersensitivity: skin reactions that may progress to systemic involvement.
  • Pancreatitis: inflammation of the pancreas presenting with abdominal pain.

Precautions & Warnings

Lamivudina Farmoz should be used with consideration of the following precautions.

  • Renal function: assess kidney function before initiating therapy and monitor periodically.
  • Hepatic function: evaluate liver enzymes and monitor for signs of hepatic impairment.
  • Pregnancy: discuss potential risks and benefits with a healthcare professional before use.
  • Breastfeeding: consider infant exposure and consult a physician regarding continuation.
  • Drug resistance: avoid monotherapy to reduce the risk of viral resistance development.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudina Farmoz can interact with other medications, affecting efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: concurrent use increases risk of severe peripheral neuropathy and pancreatitis.
  • Stavudine: combined therapy may enhance mitochondrial toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampin: may reduce lamivudine plasma concentrations, requiring monitoring.
  • Proton pump inhibitors: potential alteration of absorption, observe therapeutic response.
  • Anticoagulants (e.g., warfarin): may require INR monitoring due to possible interaction.

Frequently Asked Questions

Lamivudina Farmoz contains lamivudine, which is prescribed for managing HIV-1 infection and chronic hepatitis B infection. In both conditions, the drug helps suppress viral replication, supporting immune function and reducing disease progression when used as part of an appropriate therapeutic regimen.

Lamivudine is converted inside cells to its active triphosphate form, which mimics natural nucleosides. When HIV reverse transcriptase incorporates lamivudine triphosphate into viral DNA, it terminates the DNA chain, halting further replication of the virus and limiting infection spread.

The specific dose of Lamivudina Farmoz is determined by the prescribing healthcare professional based on the patient’s condition, weight, renal function, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety of lamivudine during pregnancy or lactation should be evaluated by a qualified healthcare provider. The prescriber will weigh potential benefits against any possible risks to the mother and child before deciding whether the medication is appropriate in these situations.

To request Lamivudina Farmoz, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class, offering a favorable safety profile and convenient oral administration. Compared with some protease inhibitors, it has fewer metabolic side effects, but it is typically used in combination with other antiretrovirals to achieve optimal viral suppression and reduce resistance risk.

Lamivudina Farmoz should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and extreme temperatures to maintain stability and potency throughout its shelf life.

Lamivudina Farmoz is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include lactic acidosis, severe hepatomegaly with steatosis, hypersensitivity reactions, and pancreatitis. Patients should promptly report symptoms such as unexplained fatigue, abdominal pain, rapid breathing, or skin rash to their healthcare provider for immediate evaluation.

Lamivudina Farmoz is contraindicated in individuals with known hypersensitivity to lamivudine or any of its excipients. Patients with severe renal impairment may require dose adjustment, and those with active liver disease should be closely monitored. The prescriber will assess suitability on a case‑by‑case basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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