Product image of Lamivudina Viatris (Lamivudine) supplied by GNH India

Lamivudina Viatris

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudina Viatris (Lamivudine)

Lamivudine, the active ingredient in Lamivudina Viatris, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as an oral tablet for oral use. It is employed in the management of Human Immunodeficiency Virus (HIV) infection and chronic hepatitis B infection in adult patients. The medication is formulated according to European Union standards and is supplied under a prescription‑only designation.

GNH India supplies Lamivudina Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our network ensures reliable delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Lamivudine is used as an antiretroviral agent targeting viral replication in specific infections.

  • Human Immunodeficiency Virus (HIV) infection: reduces viral load and helps restore immune function.
  • Chronic hepatitis B virus (HBV) infection: suppresses viral replication and improves liver enzyme levels.
  • Mother‑to‑child transmission of HIV (when used in combination therapy): lowers the risk of vertical transmission during pregnancy and delivery.
  • HIV/HBV co‑infection: provides dual antiviral activity to control both viruses simultaneously.

How It Works

  • Lamivudine is a nucleoside analogue that competes with the natural nucleoside deoxycytidine triphosphate for incorporation into viral DNA by HIV reverse transcriptase. Once incorporated, it lacks a 3′‑hydroxyl group, causing premature chain termination and halting synthesis of proviral DNA. The same mechanism applies to hepatitis B virus polymerase, leading to inhibition of HBV DNA replication.

Side Effects

Lamivudine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset.
  • Headache: transient headache.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Lactic acidosis: rare metabolic disturbance.
  • Severe hepatotoxicity: significant liver injury.
  • Stevens‑Johnson syndrome: severe skin reaction.

Precautions & Warnings

Lamivudine requires careful monitoring and patient counseling to minimize risks.

  • Liver function monitoring: assess hepatic enzymes before and during therapy.
  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Adherence counseling: emphasize consistent dosing to prevent resistance.
  • Drug interaction review: avoid concurrent use with didanosine or stavudine.
  • Pregnancy considerations: weigh potential benefits against unknown risks.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Lamivudine can interact with several medicines, necessitating review of concomitant therapies.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened peripheral neuropathy risk.
  • Other NRTIs (e.g., zidovudine) in high doses: potential mitochondrial toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: may exacerbate liver toxicity.
  • Nephrotoxic agents (e.g., tenofovir): monitor renal function.
  • Certain antiretroviral boosters (e.g., ritonavir): may alter lamivudine levels.

Frequently Asked Questions

Lamivudina Viatris contains lamivudine, which is indicated for the treatment of Human Immunodeficiency Virus (HIV) infection and chronic hepatitis B virus (HBV) infection. It is used as part of combination antiretroviral therapy to reduce viral load and improve immune function in HIV, and to suppress HBV replication and improve liver enzyme profiles in hepatitis B.

Lamivudine is a nucleoside analogue that mimics the natural building block deoxycytidine. It is phosphorylated inside cells and then incorporated by viral reverse transcriptase into the growing DNA chain. Because it lacks a 3′‑hydroxyl group, it prevents further elongation of the viral DNA, leading to chain termination and inhibition of viral replication for both HIV and hepatitis B.

The specific dose of Lamivudina Viatris is determined by the prescribing healthcare professional based on the patient’s clinical condition, weight, renal function, and treatment regimen. Standard dosing recommendations exist in clinical guidelines, but the exact amount and frequency should be set by the prescriber and not inferred from product information alone.

Safety data for lamivudine in pregnancy and lactation are limited. The drug may be prescribed during pregnancy only when the potential benefit to the mother outweighs any possible risk to the fetus, and similar caution applies to breastfeeding. Clinicians should evaluate individual circumstances and follow local regulatory guidance.

To order Lamivudina Viatris, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often compared with emtricitabine, another NRTI with a similar safety profile and potency. Both drugs are used in combination regimens, but lamivudine has a longer history of use in hepatitis B treatment, whereas emtricitabine is more commonly paired with tenofovir in HIV fixed‑dose combinations.

Lamivudina Viatris should be stored at room temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light. Do not store in a bathroom or near a heat source, and keep out of reach of children.

Lamivudina Viatris is taken orally as a tablet. The tablet should be swallowed whole with a glass of water and can be taken with or without food, unless otherwise directed by the prescriber. Consistency in timing helps maintain steady drug levels.

The most serious adverse events linked to lamivudine include lactic acidosis, severe hepatotoxicity, and hypersensitivity reactions such as Stevens‑Johnson syndrome. These conditions are rare but require immediate medical attention if symptoms such as unexplained fatigue, abdominal pain, jaundice, rash, or blistering develop.

Lamivudina Viatris should be avoided in individuals with a known hypersensitivity to lamivudine or any of the tablet’s excipients. Patients with severe hepatic impairment or uncontrolled liver disease should not use the product without careful medical supervision. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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