Product image of Lamivudina + Zidovudina Farmoz (Zidovudine, Lamivudine) supplied by GNH India

Lamivudina + Zidovudina Farmoz

Active Ingredient:
Zidovudine, Lamivudine
Origin:
EU

Lamivudina + Zidovudina Farmoz (Zidovudine, Lamivudine)

Zidovudine and Lamivudine, the active ingredient in Lamivudina + Zidovudina Farmoz, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It treats human immunodeficiency virus (HIV) infection in adults and children.

GNH India supplies Lamivudina + Zidovudina Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Lamivudina + Zidovudina is an antiretroviral medication used in the management of HIV infection and related therapeutic pathways.

  • HIV‑1 infection: reduces viral load and helps restore immune function.
  • HIV‑2 infection: suppresses viral replication and improves clinical outcomes.
  • Prevention of mother‑to‑child transmission: lowers the risk of vertical HIV transmission when administered to pregnant women.

How It Works

  • Zidovudine and lamivudine act as nucleoside analogues that are phosphorylated intracellularly to their active triphosphate forms. These active metabolites compete with natural nucleosides for incorporation into viral DNA by HIV reverse transcriptase, causing chain termination and preventing synthesis of proviral DNA, thereby inhibiting viral replication.

Side Effects

Adverse reactions may occur with Lamivudina + Zidovudina and are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal discomfort.
  • Headache: transient cranial pain.
  • Fatigue: generalised tiredness.
  • Anemia: reduction in red blood cell count.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Severe lactic acidosis: metabolic disturbance requiring urgent care.
  • Hepatic steatosis: fatty liver disease with potential liver dysfunction.
  • Severe neutropenia: marked decrease in neutrophils increasing infection risk.
  • Hypersensitivity reactions: rash, fever, or organ involvement.
  • Pancreatitis: inflammation of the pancreas with abdominal pain.

Precautions & Warnings

Before initiating therapy with Lamivudina + Zidovudina, clinicians should consider several safety measures.

  • Monitor blood counts: regular CBC to detect anemia or neutropenia.
  • Assess liver function: periodic LFTs to identify hepatic toxicity.
  • Evaluate renal function: adjust use in impaired kidneys.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution in pregnancy: weigh benefits against potential risks.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudina + Zidovudina may interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: increased risk of peripheral neuropathy and pancreatitis.
  • Stavudine: heightened mitochondrial toxicity.
  • Alcohol: potentiates hepatotoxic effects.

Moderate Interactions (Monitor Closely)

  • Rifampin: reduces plasma concentrations of both agents.
  • Antacids containing aluminium or magnesium: may impair absorption.
  • Protease inhibitors (e.g., ritonavir): alter pharmacokinetics requiring dose adjustment.

Frequently Asked Questions

Lamivudina + Zidovudina Farmoz is an antiretroviral combination containing zidovudine and lamivudine. It is prescribed to treat human immunodeficiency virus (HIV) infection in adults and children, helping to lower viral load and improve immune system function.

Zidovudine is a nucleoside reverse transcriptase inhibitor. Inside infected cells it is converted to its active triphosphate form, which competes with natural nucleotides for incorporation into viral DNA. This results in chain termination, blocking HIV reverse transcriptase and preventing viral replication.

The specific dose of Lamivudina + Zidovudina is determined by the prescribing clinician based on the patient’s age, weight, renal function, and treatment guidelines. Healthcare professionals should follow local prescribing information and adjust the regimen as needed.

Safety in pregnancy and lactation has not been definitively established. Clinicians should evaluate the potential benefits against possible risks to the fetus or infant. If treatment is essential, it may be continued under close medical supervision, following national guidelines.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamivudina + Zidovudina combines two nucleoside reverse transcriptase inhibitors, offering a dual mechanism that can simplify regimens compared with using each drug separately. Compared with newer agents, it may have a different side‑effect profile and drug‑interaction potential, which clinicians consider when selecting therapy.

The product should be stored at room temperature, below 25 °C, in its original packaging. It must be kept away from moisture, direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

Lamivudina + Zidovudina is administered orally, typically as a tablet taken with or without food. The exact administration schedule is prescribed by the treating physician and should be followed precisely to ensure optimal therapeutic effect.

Serious risks include severe lactic acidosis, hepatic steatosis, profound anemia, neutropenia, hypersensitivity reactions and pancreatitis. Patients should be monitored regularly for signs of these conditions, and any concerning symptoms should prompt immediate medical evaluation.

Individuals with known hypersensitivity to zidovudine, lamivudine, or any excipients in the formulation should avoid this product. Additionally, patients with severe bone marrow suppression or uncontrolled liver disease may be contraindicated, pending clinical assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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