Product image of Lamivudine Accord (Lamivudine) supplied by GNH India

Lamivudine Accord

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Accord (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Accord, is a nucleoside reverse transcriptase inhibitor presented as an oral dosage form for oral use. It treats Human Immunodeficiency Virus (HIV) infection and chronic hepatitis B in adults and children as prescribed. GNH India supplies Lamivudine Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Lamivudine is an antiretroviral nucleoside reverse transcriptase inhibitor used in the management of viral infections.

  • Human Immunodeficiency Virus (HIV) infection: reduces viral load and helps maintain immune function.
  • Chronic hepatitis B infection: suppresses viral replication and improves liver function.

How It Works

  • Lamivudine is taken up by cells and phosphorylated to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA by reverse transcriptase. Incorporation leads to chain termination, halting viral DNA synthesis and thereby inhibiting replication of HIV and hepatitis B virus.

Side Effects

Lamivudine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: occasional upset stomach.
  • Headache: mild to moderate intensity.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Lactic acidosis: buildup of lactate requiring immediate medical attention.
  • Severe hepatomegaly with steatosis: significant liver enlargement.
  • Pancreatitis: inflammation of the pancreas.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hypersensitivity: including rash, fever, and eosinophilia.
  • Neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Before initiating Lamivudine, clinicians should consider several safety aspects.

  • Renal function: assess kidney status in patients with impairment.
  • Hepatic function: monitor liver enzymes, especially in chronic hepatitis B.
  • Lactic acidosis monitoring: watch for unexplained fatigue, abdominal pain, or rapid breathing.
  • Pregnancy: use only if potential benefits outweigh risks.
  • Drug resistance: avoid monotherapy; combine with other antiretrovirals.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Lamivudine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened mitochondrial toxicity.
  • Zidovudine: additive bone‑marrow suppression.

Moderate Interactions (Monitor Closely)

  • Tenofovir: monitor renal function when co‑administered.
  • Protease inhibitors (e.g., ritonavir): may increase lamivudine plasma levels.
  • Antacids containing aluminum or magnesium: may reduce lamivudine absorption.

Frequently Asked Questions

Lamivudine Accord is prescribed for the treatment of Human Immunodeficiency Virus (HIV) infection and chronic hepatitis B infection. In both conditions it helps suppress viral replication, supporting immune function and liver health when used as part of an appropriate antiretroviral regimen.

Lamivudine enters cells and is converted to its active triphosphate form. This active metabolite mimics natural nucleosides and is incorporated into viral DNA by reverse transcriptase, causing premature chain termination and preventing the virus from multiplying.

The specific dose of Lamivudine Accord is determined by the prescribing clinician based on the patient’s age, weight, renal function, and the overall treatment regimen. Only a qualified health professional should set the dosage and schedule.

Safety data for lamivudine in pregnancy and lactation are limited. It should only be used if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and the decision must be made by a qualified health professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often combined with other NRTIs or drugs from different classes for optimal viral suppression. Compared with some older NRTIs, lamivudine generally has a favorable safety profile and lower mitochondrial toxicity, but resistance can develop if used as monotherapy.

Lamivudine Accord should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from excess moisture and direct sunlight to maintain its stability.

Lamivudine Accord is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed.

Serious risks include lactic acidosis, severe hepatomegaly with steatosis, pancreatitis, severe skin reactions such as Stevens‑Johnson syndrome, hypersensitivity reactions, and significant neutropenia. Patients should seek immediate medical attention if they experience symptoms suggestive of these conditions.

Lamivudine Accord should be avoided in patients with known hypersensitivity to lamivudine or any of its excipients. It is also contraindicated in individuals with severe renal impairment who cannot be appropriately dose‑adjusted, and it should not be used as monotherapy due to the risk of resistance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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