Product image of Lamivudine Aurobindo (Lamivudine) supplied by GNH India

Lamivudine Aurobindo

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Aurobindo (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Aurobindo, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for systemic use. It is employed in the management of human immunodeficiency virus (HIV) infection and chronic hepatitis B infection in adult patients, and is marketed in the European Union.

GNH India supplies Lamivudine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established distribution networks across Europe, Asia and the Americas. The company adheres to stringent quality standards and provides regulatory documentation to support import and clinical use.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Lamivudine is used as an antiretroviral and antiviral agent targeting viral replication pathways.

  • HIV infection: reduces viral load and improves immune function in adults.
  • Chronic hepatitis B infection: suppresses HBV DNA replication and helps achieve serologic response.
  • HIV‑1 infection in combination therapy: forms part of standard HAART regimens to enhance treatment efficacy.

How It Works

  • Lamivudine is a nucleoside analog that enters cells and is phosphorylated by host kinases to its active triphosphate form. The triphosphate competitively inhibits HIV reverse transcriptase and hepatitis B virus DNA polymerase, causing premature chain termination during viral DNA synthesis, thereby preventing replication of the viruses. The intracellular accumulation of the active metabolite is sustained, allowing once‑daily dosing in many regimens, and its selective affinity for viral enzymes minimizes impact on host DNA polymerases.

Side Effects

Lamivudine may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Fatigue: general tiredness reported by some patients.
  • Diarrhea: loose stools, usually transient.

Serious or Rare Side Effects

  • Lactic acidosis: rare metabolic complication requiring immediate medical attention.
  • Severe hepatotoxicity: marked liver enzyme elevation or liver failure.
  • Pancreatitis: inflammation of the pancreas presenting with abdominal pain.

Precautions & Warnings

When prescribing Lamivudine, clinicians should consider several precautionary measures to ensure safe use.

  • Renal function: assess creatinine clearance and adjust dose in severe impairment.
  • Hepatic disease: monitor liver enzymes regularly in patients with existing liver conditions.
  • Pregnancy: evaluate risk‑benefit ratio, as safety data are limited.
  • Concomitant medications: review for potential drug‑drug interactions before initiating therapy.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: co‑administration increases risk of pancreatitis and hepatic toxicity.
  • Stavudine: combined use may exacerbate mitochondrial toxicity and lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Tenofovir: may require renal function monitoring due to additive nephrotoxic potential.
  • Efavirenz: can affect Lamivudine plasma levels; monitor viral load.
  • Rifampicin: induces hepatic enzymes, potentially reducing Lamivudine concentrations.

Frequently Asked Questions

Lamivudine Aurobindo is indicated for the treatment of adult patients with human immunodeficiency virus (HIV) infection and for chronic hepatitis B infection. In both cases the drug works to suppress viral replication, helping to control disease progression.

Lamivudine is a nucleoside analog that is taken up by cells and phosphorylated to its active triphosphate form. This active metabolite competes with natural nucleotides for the active site of HIV reverse transcriptase and hepatitis B virus DNA polymerase, causing premature termination of viral DNA chains and blocking replication.

The dosage of Lamivudine Aurobindo is determined by the prescribing healthcare professional based on the individual’s clinical condition, weight, renal function and other factors. Patients should follow the dose and schedule provided by their prescriber and not adjust the regimen on their own.

Safety data for lamivudine in pregnancy and lactation are limited. The drug may be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should assess each case individually and discuss potential risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any required import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often combined with other antiretrovirals for optimal viral suppression. Compared with some alternatives, it has a favorable safety profile and convenient oral dosing, but resistance patterns and individual patient factors may influence the choice of regimen.

Lamivudine Aurobindo should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and extreme temperature fluctuations to maintain potency throughout its shelf life.

Lamivudine Aurobindo is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically advised by a healthcare professional.

Serious adverse events, although rare, include lactic acidosis, severe hepatotoxicity and pancreatitis. Patients should be monitored for signs such as unexplained fatigue, abdominal pain, jaundice or rapid weight loss, and any concerning symptoms should prompt immediate medical evaluation.

Lamivudine Aurobindo should be avoided in patients with known hypersensitivity to lamivudine or any of the tablet excipients. Caution is also advised for individuals with severe renal impairment, active liver disease, or those taking medications that have major interaction risks, unless close monitoring is possible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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