Product image of Lamivudine Milpharm (Lamivudine) supplied by GNH India

Lamivudine Milpharm

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Milpharm (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Milpharm, is a nucleoside reverse transcriptase inhibitor presented as a tablet for oral use. It treats HIV‑1 infection and chronic hepatitis B infection in adults.
GNH India supplies Lamivudine Milpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Milpharm Limited

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Indications & Clinical Uses

Lamivudine is used in the management of viral infections that rely on reverse transcription.

  • HIV‑1 infection: suppresses viral replication and improves immune function.
  • Chronic hepatitis B infection: reduces viral load and slows liver disease progression.
  • Prevention of mother‑to‑child transmission of HIV: lowers the risk of vertical transmission when combined with other antiretrovirals.

How It Works

  • Lamivudine acts as a nucleoside analogue of cytidine. After intracellular phosphorylation to its active triphosphate form, it competes with natural nucleotides for incorporation into viral DNA by HIV reverse transcriptase and hepatitis B polymerase, causing premature chain termination and halting viral genome synthesis.

Side Effects

Lamivudine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional, often transient.
  • Fatigue: generalized tiredness without specific cause.
  • Diarrhoea: loose stools, usually self‑limiting.

Serious or Rare Side Effects

  • Lactic acidosis: metabolic disturbance requiring immediate medical attention.
  • Severe hepatotoxicity: marked elevation of liver enzymes or liver failure, especially in patients with pre‑existing liver disease.

Precautions & Warnings

Before prescribing Lamivudine, clinicians should consider several safety aspects.

  • Renal function: adjust dose in patients with impaired clearance.
  • Hepatic disease: monitor liver enzymes regularly.
  • Co‑infection: assess for hepatitis C or other viral infections.
  • Pregnancy: weigh potential benefits against unknown risks.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Lamivudine can affect, and be affected by, other medicines.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis and mitochondrial toxicity.
  • Stavudine: heightened potential for peripheral neuropathy and lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Rifampicin: may reduce lamivudine plasma concentrations.
  • Antacids containing aluminium or magnesium: can lower absorption if taken simultaneously.
  • Concomitant use of other nucleoside analogues: monitor for additive mitochondrial toxicity.

Frequently Asked Questions

Lamivudine Milpharm is indicated for the treatment of HIV‑1 infection and for chronic hepatitis B infection in adults. It is also employed as part of combination regimens to reduce the risk of mother‑to‑child transmission of HIV when used with other antiretroviral agents.

Lamivudine is a nucleoside analogue that, after cellular phosphorylation, mimics natural nucleotides. When incorporated into viral DNA by reverse transcriptase, it terminates the growing DNA chain, preventing the virus from replicating its genome and thereby limiting infection.

The specific dose of Lamivudine Milpharm is determined by the prescribing clinician based on the patient’s condition, weight, renal function and other individual factors. Healthcare professionals set the appropriate regimen according to current treatment guidelines.

Safety data for lamivudine in pregnancy and lactation are limited. Clinicians must weigh the potential benefits for the mother against any unknown risks to the fetus or infant, and use the drug only when clearly indicated.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor class, offering a favorable safety profile and once‑daily dosing in many regimens. Compared with older NRTIs such as zidovudine, it has fewer mitochondrial toxicities, but it is often combined with other agents to achieve optimal viral suppression.

Lamivudine Milpharm should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its potency throughout its shelf life.

The medication is taken orally, usually as a tablet, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether the dose should be taken with meals to ensure consistent absorption.

Serious adverse events, although rare, include lactic acidosis, severe hepatotoxicity, and mitochondrial toxicity leading to peripheral neuropathy. Prompt medical evaluation is required if patients experience unexplained abdominal pain, rapid weight loss, or signs of liver dysfunction.

Lamivudine is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with severe renal impairment, active hepatitis, or those receiving interacting medications such as didanosine or stavudine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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