Product image of Lamivudine Mylan (Lamivudine) supplied by GNH India

Lamivudine Mylan

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Mylan (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Mylan, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as an oral tablet for oral use. It is indicated for the treatment of HIV infection and chronic hepatitis B in adults and pediatric patients, where it is prescribed as part of combination antiretroviral therapy or as monotherapy for hepatitis B, helping to suppress viral replication.

GNH India supplies Lamivudine Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including both public and private healthcare networks.

Manufacturer / TM Owner

Generics [uk] Limited

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Indications & Clinical Uses

Lamivudine is used to treat viral infections that involve reverse transcriptase activity, primarily HIV and hepatitis B.

  • HIV infection: reduces viral load and slows disease progression as part of combination antiretroviral therapy.
  • Chronic hepatitis B: suppresses hepatitis B virus replication and improves liver function when used alone or with other antivirals.
  • HIV/HBV co‑infection: provides dual antiviral activity to manage both viruses concurrently.

How It Works

  • Lamivudine is a nucleoside analogue that enters cells and is phosphorylated by host kinases to its active triphosphate form. The triphosphate competes with natural deoxycytidine triphosphate for incorporation into viral DNA by reverse transcriptase. Once incorporated, it lacks a 3′‑hydroxyl group, causing premature chain termination and preventing synthesis of proviral DNA, thereby inhibiting replication of HIV and hepatitis B virus.

Side Effects

Lamivudine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic disturbance requiring immediate medical attention.
  • Hepatotoxicity: significant liver enzyme elevations or hepatitis.
  • Severe rash: including Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing lamivudine, clinicians should consider several precautionary measures to ensure safe use.

  • Renal function: adjust dose in patients with impaired kidney function.
  • Hepatic disease: monitor liver enzymes in patients with existing liver disease.
  • Pregnancy: evaluate risk‑benefit ratio before use in pregnant women.
  • Concomitant medications: review for potential drug interactions, especially with other antiretrovirals.
  • Adherence: emphasize importance of consistent dosing to prevent resistance.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Lamivudine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: concurrent use increases risk of pancreatitis.
  • Stavudine: combined use may enhance mitochondrial toxicity.

Moderate Interactions (Monitor Closely)

  • Tenofovir: may require renal function monitoring.
  • Efavirenz: may affect lamivudine plasma levels.
  • Rifampicin: can reduce lamivudine concentrations.

Frequently Asked Questions

Lamivudine Mylan is a prescription‑only oral medication used to treat HIV infection and chronic hepatitis B. In HIV, it is part of combination antiretroviral therapy to lower viral load. For hepatitis B, it can be used alone or with other antivirals to suppress viral replication and improve liver health.

Lamivudine is a nucleoside analogue that is converted inside cells to its active triphosphate form. This active metabolite competes with natural nucleotides for incorporation by the viral reverse transcriptase enzyme. Once incorporated, it lacks a 3′‑hydroxyl group, causing premature termination of the viral DNA chain and blocking replication of HIV and hepatitis B virus.

The specific dose of lamivudine is determined by the prescribing clinician based on the patient’s age, weight, renal function, and the condition being treated. Dosage regimens differ for HIV versus hepatitis B and may be adjusted when used in combination with other antiretroviral agents.

Safety of lamivudine in pregnancy and lactation should be evaluated by the treating physician. The drug is classified as Category C in many regions, indicating that potential benefits may justify use despite limited data. Breastfeeding decisions should consider the infant’s exposure and the mother’s clinical status.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lamivudine Mylan. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class, offering a favorable safety profile and once‑daily dosing in many regimens. Compared with older NRTIs such as zidovudine, lamivudine has fewer mitochondrial toxicities. When combined with drugs from other classes (e.g., integrase inhibitors), it contributes to potent, durable viral suppression.

Store Lamivudine Mylan at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Lamivudine Mylan is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing schedule provided by their healthcare professional and not miss doses.

Serious adverse events, although rare, include lactic acidosis, severe hepatotoxicity, and life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience unexplained abdominal pain, rapid breathing, yellowing of the skin or eyes, or a severe rash.

Lamivudine Mylan should be avoided in individuals with known hypersensitivity to lamivudine or any of the tablet’s excipients. Caution is also advised for patients with severe renal impairment, active liver disease, or those taking medications that have major interactions, such as didanosine or stavudine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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