Product image of Lamivudine Teva (Lamivudine) supplied by GNH India

Lamivudine Teva

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Teva (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Teva, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It treats HIV infection and chronic hepatitis B in adults and children as prescribed.

GNH India supplies Lamivudine Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lamivudine is used in antiretroviral therapy and antiviral treatment of hepatitis B, targeting viral replication pathways.

  • HIV infection: reduces viral load and slows disease progression when used in combination antiretroviral regimens.
  • Chronic hepatitis B: suppresses HBV DNA replication and improves liver function in infected patients.
  • Prevention of mother‑to‑child HIV transmission: lowers the risk of vertical transmission when administered to pregnant women as part of combination therapy.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural deoxycytidine nucleotides for incorporation into viral DNA. By acting as a chain terminator, it inhibits HIV reverse transcriptase and hepatitis B virus polymerase, preventing elongation of the viral genome and thereby suppressing replication.

Side Effects

Lamivudine may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Headache
  • Fatigue
  • Diarrhea
  • Abdominal pain
  • Insomnia

Serious or Rare Side Effects

  • Lactic acidosis
  • Severe hepatotoxicity
  • Pancreatitis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Bone marrow suppression
  • Hypersensitivity reactions (e.g., rash, fever).

Precautions & Warnings

When prescribing Lamivudine, clinicians should consider several safety and handling precautions.

  • Renal function: adjust dose in patients with severe renal impairment.
  • Hepatic disease: monitor liver enzymes regularly.
  • Pregnancy: evaluate risk‑benefit before use.
  • Concomitant medications: review for potential interactions.
  • Adherence: emphasize importance of consistent dosing to prevent resistance.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Avoid Interactions

Lamivudine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened mitochondrial toxicity.
  • Zidovudine: additive bone marrow suppression.
  • Co‑administration with other NRTIs causing overlapping toxicity.
  • Nephrotoxic agents: may worsen renal function.

Moderate Interactions (Monitor Closely)

  • Protease inhibitors (e.g., ritonavir): may increase lamivudine levels.
  • Non‑nucleoside reverse transcriptase inhibitors (e.g., efavirenz): may affect plasma concentrations.
  • Antacids containing aluminum or magnesium: may reduce absorption.
  • Warfarin: monitor INR as lamivudine may alter anticoagulant effect.
  • Live vaccines: may have reduced efficacy.

Frequently Asked Questions

Lamivudine Teva is an oral nucleoside reverse transcriptase inhibitor indicated for the treatment of HIV infection and chronic hepatitis B. It is used as part of combination antiretroviral therapy for HIV and as monotherapy or in combination for hepatitis B viral suppression.

Lamivudine is converted inside cells to its active triphosphate form, which mimics natural nucleosides. When incorporated into viral DNA by reverse transcriptase or HBV polymerase, it terminates the growing DNA chain, thereby blocking viral replication.

The specific dose of lamivudine is determined by the prescribing clinician based on the patient’s condition, age, renal function and treatment regimen. Patients should follow the dose prescribed by their healthcare professional.

Safety data for lamivudine in pregnancy and lactation are limited. The drug may be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Lamivudine Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with a favorable safety profile and once‑daily dosing options. Compared with older NRTIs, it has lower mitochondrial toxicity and is often combined with other classes such as protease inhibitors or integrase inhibitors to achieve potent viral suppression.

Lamivudine Teva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Lamivudine Teva is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events associated with lamivudine include lactic acidosis, severe hepatotoxicity, pancreatitis, bone marrow suppression and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience unexplained fatigue, abdominal pain, jaundice, rash or respiratory distress.

Lamivudine is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is also advised for individuals with severe renal impairment, active liver disease, or those receiving medications that have major interacting potential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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