Product image of Lamivudine Teva (Lamivudine) supplied by GNH India

Lamivudine Teva

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Teva (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Teva, is a nucleoside reverse transcriptase inhibitor (NRTI) presented as a tablet for oral use. It treats HIV infection and chronic hepatitis B infection in adults.

GNH India supplies Lamivudine Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lamivudine is an antiretroviral nucleoside analogue used to manage viral infections that rely on reverse transcription.

  • HIV infection: reduces viral load and helps restore immune function.
  • Chronic hepatitis B infection: suppresses HBV replication and lowers liver inflammation.
  • HIV/HBV co‑infection: provides simultaneous control of both viruses in patients with dual infection.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA by reverse transcriptase. Incorporation results in premature chain termination, halting synthesis of viral DNA and thereby inhibiting replication of HIV and hepatitis B virus.

Side Effects

Lamivudine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Fatigue: feeling of tiredness or lack of energy.
  • Diarrhoea: loose stools, usually self‑limiting.

Serious or Rare Side Effects

  • Lactic acidosis: buildup of lactate leading to metabolic disturbance.
  • Severe hepatotoxicity: significant liver enzyme elevation or liver failure.

Precautions are essential to minimise risk.

Precautions & Warnings

Lamivudine requires careful monitoring in several clinical situations.

  • Renal function: assess creatinine clearance and adjust dose if needed.
  • Hepatic impairment: monitor liver enzymes regularly.
  • Pregnancy: benefits must outweigh potential unknown risks; consult obstetric specialist.
  • Concomitant didanosine: avoid due to increased pancreatitis risk.
  • Resistance testing: perform baseline HIV resistance assay before initiation.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudine may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: combined use raises pancreatitis risk.
  • Stavudine: may increase peripheral neuropathy.
  • Tenofovir: potential additive renal toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampin: induces metabolism, reducing lamivudine levels.
  • Antacids containing aluminium or magnesium: may impair absorption.
  • Alcohol: can exacerbate liver injury, especially in hepatitis B patients.

Frequently Asked Questions

Lamivudine Teva is indicated for the treatment of HIV infection and chronic hepatitis B infection. It is also employed in patients who have both HIV and hepatitis B, helping to control viral replication of each pathogen.

Lamivudine is converted inside cells to its active triphosphate form, which mimics natural nucleosides. When reverse transcriptase incorporates lamivudine triphosphate into viral DNA, it causes chain termination, preventing the virus from completing its genetic material and thereby halting replication.

The specific dose of Lamivudine Teva is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and other individual factors. Healthcare professionals follow approved dosing guidelines and adjust as needed.

Safety data for lamivudine in pregnancy are limited, and the drug is classified as pregnancy category unknown. Clinicians must weigh potential benefits against possible risks, and breastfeeding decisions should be made in consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often combined with other antiretrovirals for synergistic effect. Compared with newer agents, lamivudine has a well‑established safety profile, but resistance can develop if used as monotherapy, making combination regimens preferred.

Lamivudine tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Do not store in humid environments such as bathrooms or near heat sources.

Lamivudine Teva is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with water and not chewed or crushed unless specifically advised by a healthcare professional.

The most serious adverse events include lactic acidosis, severe hepatotoxicity, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should be monitored for unexplained fatigue, abdominal pain, rapid breathing, or skin eruptions and seek immediate medical attention if they occur.

Lamivudine is contraindicated in patients with known hypersensitivity to lamivudine or any of its excipients. Caution is also advised for individuals with severe renal impairment, active liver disease, or those taking contraindicated medications such as didanosine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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