Product image of Lamivudine Teva Pharma (Lamivudine) supplied by GNH India

Lamivudine Teva Pharma

Active Ingredient:
Lamivudine
Origin:
EU

Lamivudine Teva Pharma (Lamivudine)

Lamivudine, the active ingredient in Lamivudine Teva, is a nucleoside reverse transcriptase inhibitor presented as an oral dosage form for oral use. It treats HIV-1 infection and chronic hepatitis B in adults, helping to suppress viral replication and improve immune function.

GNH India supplies Lamivudine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lamivudine is used in antiretroviral therapy and hepatitis B management, targeting viral replication pathways.

  • HIV-1 infection: reduces plasma viral load and helps restore CD4+ T‑cell counts.
  • Chronic hepatitis B infection: suppresses HBV DNA synthesis and lowers liver inflammation.
  • Prevention of mother‑to‑child transmission of HIV: decreases the risk of vertical transmission during pregnancy and delivery.

How It Works

  • Lamivudine is phosphorylated intracellularly to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA. By binding to HIV‑1 reverse transcriptase and hepatitis B virus DNA polymerase, it causes premature chain termination, halting viral genome synthesis and limiting replication.

Side Effects

Lamivudine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Fatigue: reduced energy levels.
  • Diarrhea: loose stools.
  • Insomnia: difficulty sleeping.
  • Abdominal pain: mild cramping.

Serious or Rare Side Effects

  • Lactic acidosis: severe metabolic disturbance.
  • Hepatic steatosis: fatty liver disease.
  • Pancreatitis: inflammation of the pancreas.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Neutropenia: low white‑blood‑cell count.
  • Anemia: reduced red‑blood‑cell levels.

Precautions & Warnings

Before prescribing lamivudine, clinicians should consider several safety factors.

  • Renal impairment: assess kidney function and adjust dose if needed.
  • Hepatic impairment: monitor liver enzymes regularly.
  • Pregnancy: category B; use when benefits outweigh potential risks.
  • Lactation: minimal drug excretion in breast milk; monitor infant.
  • Resistance development: perform viral load testing to detect resistance.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Lamivudine may interact with other medicines, requiring vigilance.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened peripheral neuropathy risk.
  • Ribavirin: additive toxicity, especially hematologic.

Moderate Interactions (Monitor Closely)

  • Efavirenz: possible reduction in lamivudine plasma levels.
  • Tenofovir: combined renal toxicity potential.
  • Alcohol: may exacerbate liver injury.

Frequently Asked Questions

Lamivudine Teva is prescribed for the treatment of HIV‑1 infection and chronic hepatitis B infection. It helps suppress viral replication, lower viral load, and improve immune function in these conditions.

Lamivudine is converted inside cells to its active triphosphate form, which competes with natural nucleosides for incorporation into viral DNA. This results in premature chain termination, blocking HIV‑1 reverse transcriptase and hepatitis B virus DNA polymerase activity.

The dosage of lamivudine is individualized by the prescribing clinician based on the patient’s condition, weight, renal function, and other factors. Patients should follow the exact regimen provided by their healthcare professional.

Lamivudine is classified as pregnancy category B, indicating no evidence of risk in animal studies and limited human data. It may be used when the therapeutic benefit justifies potential risks. Small amounts are excreted in breast milk; clinicians should weigh benefits and monitor the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lamivudine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class and is often combined with other antiretrovirals for synergistic effect. Compared with older NRTIs, it has a favorable safety profile, lower mitochondrial toxicity, and is active against both HIV‑1 and hepatitis B virus.

Lamivudine tablets should be stored at room temperature, below 25 °C, in the original container to protect from moisture and light. Do not store in humid or excessively hot environments.

Lamivudine Teva is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed.

Serious adverse events, though rare, include lactic acidosis, hepatic steatosis, severe skin reactions such as Stevens‑Johnson syndrome, pancreatitis, neutropenia, and anemia. Patients should seek immediate medical attention if they experience unexplained abdominal pain, rapid breathing, or severe skin rash.

Lamivudine is contraindicated in patients with known hypersensitivity to lamivudine or any of its excipients. Caution is advised for individuals with severe renal or hepatic impairment, and it should be avoided in combination with contraindicated drugs such as didanosine or stavudine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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