Product image of Lamivudine/Zidovudine Aurobindo (Zidovudine, Lamivudine) supplied by GNH India

Lamivudine/Zidovudine Aurobindo

Active Ingredient:
Zidovudine, Lamivudine
Origin:
EU

Lamivudine/Zidovudine Aurobindo (Zidovudine, Lamivudine)

Lamivudine/Zidovudine, the active ingredient in Lamivudine/Zidovudine Aurobindo, is a nucleoside reverse transcriptase inhibitor presented as an oral tablet for oral use. It treats HIV-1 infection in adults and children, often as part of combination antiretroviral therapy.

GNH India supplies Lamivudine/Zidovudine Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

Lamivudine/Zidovudine is an antiretroviral medication that targets HIV replication within the nucleoside reverse transcriptase pathway.

  • HIV-1 infection (adults): reduces viral load when used in combination regimens.
  • HIV-1 infection (children): provides pediatric dosing options within fixed‑dose combinations.
  • Prevention of mother‑to‑child transmission: used during pregnancy to lower transmission risk.
  • HIV-1 infection (combined therapy): enhances efficacy of other NRTIs and protease inhibitors.

How It Works

  • Lamivudine and zidovudine are phosphorylated inside cells to their active triphosphate forms, which compete with natural nucleosides for incorporation into viral DNA by reverse transcriptase. Their incorporation results in chain termination, halting HIV replication and reducing viral load.

Side Effects

Lamivudine/Zidovudine may cause a range of adverse reactions. Patients should be monitored regularly for any signs of toxicity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Fatigue: general tiredness or weakness.
  • Diarrhea: loose stools, often self‑limiting.

Serious or Rare Side Effects

  • Severe lactic acidosis: metabolic emergency requiring immediate care.
  • Hepatotoxicity: liver enzyme elevations or hepatitis.
  • Bone marrow suppression: anemia, neutropenia, or thrombocytopenia.
  • Hypersensitivity reactions: rash, fever, or organ involvement.
  • Pancreatitis: abdominal pain with elevated enzymes.

Precautions & Warnings

Before prescribing Lamivudine/Zidovudine, clinicians should consider several safety factors.

  • Renal function: assess and adjust in severe impairment.
  • Hepatic function: monitor liver enzymes regularly.
  • Hematologic status: perform baseline and periodic CBC to detect anemia or neutropenia.
  • Pregnancy: category B; weigh maternal benefits against potential fetal risks.
  • Drug resistance: avoid using as monotherapy to prevent resistance development.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudine/Zidovudine can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Didanosine: increased risk of pancreatitis.
  • Stavudine: heightened mitochondrial toxicity.
  • Alcohol: may exacerbate hepatotoxic effects.

Moderate Interactions (Monitor Closely)

  • Nephrotoxic agents: monitor renal function when co‑administered.
  • Anticoagulants (e.g., warfarin): possible alteration of INR.
  • Live vaccines: reduced immunogenic response, consider timing of vaccination.

Frequently Asked Questions

Lamivudine/Zidovudine is used as part of combination antiretroviral therapy to treat HIV-1 infection in adults, children, and pregnant women, helping to suppress viral replication and improve immune function.

Both lamivudine and zidovudine are nucleoside analogues that are converted inside cells to active triphosphates. These molecules are incorporated into viral DNA by reverse transcriptase, causing chain termination and preventing HIV from multiplying.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s age, weight, renal function, and overall treatment regimen. Patients should follow the prescriber’s instructions exactly.

Lamivudine/Zidovudine is classified as pregnancy category B, indicating no evidence of risk in animal studies and limited human data. It may be used when the benefits to the mother outweigh potential risks, and breastfeeding decisions should be made with a healthcare professional.

Enquiries can be submitted on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lamivudine/Zidovudine combines two NRTIs, offering a synergistic effect that can improve viral suppression compared with single‑agent NRTI therapy. It is often preferred in fixed‑dose combinations for its established efficacy and safety profile.

Store the tablets at room temperature, below 25 °C, in the original container. Protect from moisture, heat and direct sunlight to maintain product stability.

The medication is taken orally, usually with or without food, as directed by the prescriber. Swallow tablets whole with water; do not crush or chew unless specifically instructed.

Serious risks include severe lactic acidosis, hepatotoxicity, bone‑marrow suppression (anemia, neutropenia), hypersensitivity reactions, and pancreatitis. Patients should be monitored regularly for these events.

Patients with known hypersensitivity to lamivudine, zidovudine, or any excipients in the formulation should avoid this product. It should also be used with caution in individuals with severe hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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