Product image of Lamotrigin Stada (Lamotrigine) supplied by GNH India

Lamotrigin Stada

Active Ingredient:
Lamotrigine
Origin:
EU

Lamotrigin Stada (Lamotrigine)

Lamotrigine, the active ingredient in Lamotrigin Stada, is an anticonvulsant presented as an oral tablet for oral use. Classified under ATC code N03AX12, it is prescribed for the management of epilepsy, bipolar disorder, and migraine prevention in adult patients. It is widely used across Europe and other regions.

GNH India supplies Lamotrigin Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to strict quality standards and regulatory requirements, and providing the product for both acute and maintenance therapy.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Lamotrigine is an anticonvulsant that is used in several neurological and psychiatric conditions.

  • Epilepsy: reduces seizure frequency and helps achieve seizure control.
  • Bipolar disorder: stabilizes mood and decreases the frequency of manic and depressive episodes.
  • Migraine prophylaxis: lowers the number of migraine attacks when taken regularly.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels in neuronal membranes, which stabilises hyper‑excitable neuronal tissue and diminishes the release of excitatory neurotransmitters such as glutamate. By reducing neuronal firing, it helps prevent the propagation of seizure activity and modulates mood‑related pathways, contributing to its efficacy in epilepsy, bipolar disorder and migraine prevention. The drug preferentially binds to the inactivated state of the sodium channel, prolonging the refractory period and further limiting abnormal neuronal discharge.

Side Effects

Lamotrigine may cause a range of adverse reactions, which are categorised by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or imbalance.
  • Headache: mild to moderate pain in the head.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Rash: mild skin redness or itching.
  • Fatigue: feeling of tiredness or lack of energy.
  • Blurred vision: temporary loss of visual clarity.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction with blistering and mucosal involvement.
  • Aseptic meningitis: inflammation of the meninges without infection, presenting with fever and neck stiffness.
  • Blood dyscrasias: including agranulocytosis or severe neutropenia.

Precautions & Warnings

When prescribing Lamotrigin Stada, clinicians should observe several safety measures.

  • Initiate therapy at low dose: start with a low dose and increase gradually to reduce rash risk.
  • Monitor skin reactions: discontinue immediately if a widespread rash or signs of Stevens‑Johnson syndrome appear.
  • Assess hepatic function: use caution in patients with liver impairment and adjust monitoring.
  • Avoid abrupt discontinuation: taper the dose under medical supervision to prevent seizure worsening.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Lamotrigin Stada can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Valproic acid: markedly increases lamotrigine plasma levels, raising risk of toxicity.
  • Carbamazepine: reduces lamotrigine concentrations, potentially decreasing efficacy.
  • Phenobarbital: lowers lamotrigine levels, may lead to loss of seizure control.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may decrease lamotrigine levels, requiring dose adjustment.
  • Serotonergic agents: combined use may increase risk of serotonin syndrome, monitor symptoms.
  • Antifungal azoles (e.g., fluconazole): can modestly raise lamotrigine concentrations, watch for side effects.

Frequently Asked Questions

Lamotrigin Stada contains lamotrigine, which is indicated for the treatment of epilepsy to control seizures, for bipolar disorder as a mood stabiliser to reduce manic and depressive episodes, and for migraine prophylaxis to decrease the frequency of migraine attacks when taken regularly.

Lamotrigine works by inhibiting voltage‑gated sodium channels on neuronal membranes, stabilising hyper‑excitable cells and reducing the release of excitatory neurotransmitters such as glutamate. This action limits abnormal neuronal firing, helping to prevent seizure propagation and modulating pathways involved in mood regulation and migraine generation.

The appropriate dose of Lamotrigin Stada is determined by the prescribing healthcare professional based on the individual’s medical condition, age, renal and hepatic function, and any concomitant medications. Dosage titration is usually gradual to minimise the risk of skin reactions, and patients should follow the prescriber’s instructions exactly.

Lamotrigine’s pregnancy category is not definitively established; it is classified as ‘unknown’ in many regions. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their physician, as the drug may cross the placenta and appear in breast milk, requiring careful clinical assessment.

To request Lamotrigin Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any necessary import documentation.

Lamotrigine is distinguished by its broad spectrum of activity, efficacy in both focal and generalized seizures, and a relatively favourable cognitive profile compared with some older antiepileptics. Unlike enzyme‑inducing agents such as carbamazepine, lamotrigine has fewer drug‑inducing interactions, though it requires careful monitoring when combined with valproic acid or hormonal contraceptives.

Lamotrigin Stada should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light, and store them out of reach of children. Do not refrigerate or freeze the product.

Lamotrigin Stada is taken orally, usually as a tablet swallowed whole with water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal upset. The exact schedule and titration plan are set by the prescriber to achieve therapeutic levels while minimising adverse effects.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, which require immediate discontinuation and medical attention. Rare but critical risks also comprise aseptic meningitis and blood dyscrasias like agranulocytosis or severe neutropenia, which necessitate prompt evaluation and possible cessation of therapy.

Lamotrigine should be avoided in individuals with a known hypersensitivity to the drug or any of its components. Patients with severe hepatic impairment may require special consideration, and those with a history of serious rash or skin reactions should not restart the medication without thorough medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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