Product image of Lamotrigina Accord (Lamotrigine) supplied by GNH India

Lamotrigina Accord

Active Ingredient:
Lamotrigine
Origin:
EU

Lamotrigina Accord (Lamotrigine)

Lamotrigine, the active ingredient in Lamotrigina Accord, is a sodium channel blocker presented as oral tablets for oral use. It treats epilepsy, including partial and generalized tonic‑clonic seizures, and is used as maintenance therapy for bipolar disorder in adults.
GNH India supplies Lamotrigina Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Lamotrigine acts on neuronal sodium channels to control seizure activity and mood stabilization.

  • Partial seizures: reduces frequency of focal seizures.
  • Generalized tonic‑clonic seizures: lowers occurrence of convulsive episodes.
  • Bipolar disorder (maintenance): helps maintain mood stability and prevents relapse.

How It Works

  • Lamotrigine inhibits voltage‑gated sodium channels, decreasing neuronal excitability and stabilising membrane potentials. This action reduces the release of excitatory neurotransmitters such as glutamate, thereby limiting seizure propagation and modulating mood‑related pathways.

Side Effects

Lamotrigine may cause a range of adverse reactions.

Common Side Effects

  • Dizziness
  • Headache
  • Nausea
  • Rash (mild)
  • Blurred vision
  • Fatigue

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe skin reactions (e.g., drug reaction with eosinophilia and systemic symptoms)
  • Blood dyscrasias such as agranulocytosis
  • Hepatic failure
  • Suicidal thoughts or behavior
  • Severe hypersensitivity reactions

Precautions & Warnings

Lamotrigine requires careful monitoring and patient education.

  • Monitor serum levels: adjust dose when interacting medications are added or removed.
  • Assess hepatic function: lamotrigine is metabolised in the liver and may need adjustment in impairment.
  • Avoid abrupt discontinuation: sudden stop can precipitate seizure recurrence.
  • Use caution in pregnancy: classified as Category C; discuss potential risks with a healthcare professional.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lamotrigine interacts with several drugs that can alter its plasma concentration.

Major Interactions (Avoid)

  • Valproic acid: markedly increases lamotrigine levels, risk of toxicity.
  • Carbamazepine: reduces lamotrigine concentrations, may diminish efficacy.
  • Phenytoin: lowers lamotrigine exposure, requiring dose adjustment.
  • Oral contraceptives: increase lamotrigine levels, may need monitoring.

Moderate Interactions (Monitor Closely)

  • Other enzyme‑inducing antiepileptics (e.g., phenobarbital): may decrease lamotrigine levels.
  • Serotonergic agents: potential for additive central nervous system effects.
  • NSAIDs: may increase risk of rash when combined with lamotrigine.

Frequently Asked Questions

Lamotrigina Accord contains lamotrigine, which is prescribed for the treatment of epilepsy—including partial and generalized tonic‑clonic seizures—and as a maintenance therapy to help stabilize mood in adults with bipolar disorder.

Lamotrigine blocks voltage‑gated sodium channels on neurons, reducing abnormal electrical activity and limiting the release of excitatory neurotransmitters such as glutamate. This stabilises neuronal membranes, decreasing seizure frequency and contributing to mood regulation.

The specific dose of Lamotrigina Accord is determined by the prescribing clinician based on the individual’s diagnosis, age, renal and hepatic function, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Lamotrigine is classified as Pregnancy Category C, meaning risk cannot be ruled out. It should only be used during pregnancy if the potential benefit justifies the potential risk. Limited data are available for breastfeeding; a healthcare professional should evaluate the risk‑benefit ratio.

To request Lamotrigina Accord, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium channel blockers such as carbamazepine, lamotrigine generally has a more favourable side‑effect profile, especially regarding cognitive effects. However, it requires careful titration to minimise rash risk and has notable interactions with enzyme‑inducing agents, which differ from some alternatives.

Lamotrigina Accord should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless otherwise specified by the supplier.

Lamotrigina Accord is taken orally, usually as a tablet, with or without food as directed by the prescriber. The medication is typically started at a low dose and gradually increased to the target dose to reduce the risk of skin reactions.

The most serious risks include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, blood dyscrasias, hepatic failure, and the emergence of suicidal thoughts or behaviors. Patients should seek immediate medical attention if they notice any concerning symptoms.

Lamotrigina Accord is contraindicated in individuals with a known hypersensitivity to lamotrigine or any of its excipients. Caution is also advised for patients with severe hepatic impairment, those taking interacting enzyme‑inducing drugs without proper dose adjustment, and pregnant women unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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